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Titolo:
Soluble products from Eikenella corrodens stimulate oral epithelial cells to induce inflammatory mediators
Autore:
Yumoto, H; Nakae, H; Yamada, M; Fujinaka, K; Shinohara, C; Ebisu, S; Matsuo, T;
Indirizzi:
Univ Tokushima, Sch Dent, Dept Conservat Dent, Tokushima, Japan Univ Tokushima Tokushima Japan t, Dept Conservat Dent, Tokushima, Japan Osaka Univ, Grad Sch Dent, Dept Restorat Dent & Endodontol, Suita, Osaka 565, Japan Osaka Univ Suita Osaka Japan 565 nt & Endodontol, Suita, Osaka 565, Japan
Titolo Testata:
ORAL MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 5, volume: 16, anno: 2001,
pagine: 296 - 305
SICI:
0902-0055(200110)16:5<296:SPFECS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINGIVAL CREVICULAR FLUID; GROWTH-FACTOR RECEPTOR; MESSENGER-RNA; PERIODONTAL-DISEASE; PROSTAGLANDIN E-2; IN-VITRO; CHEMOTACTIC CYTOKINES; EXPRESSION; INTERLEUKIN-8; CYCLOOXYGENASE-2;
Keywords:
Eikenella corrodens; oral epithelial cells; prostaglandin E-2; interleukin-6; interleukin-8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Yumoto, H Univ Tokushima, Sch Dent, Dept Conservat Dent, 3-18-15 Kuramoto Cho, Tokushima, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japanima, Japan
Citazione:
H. Yumoto et al., "Soluble products from Eikenella corrodens stimulate oral epithelial cells to induce inflammatory mediators", ORAL MICROB, 16(5), 2001, pp. 296-305

Abstract

In the inflammatory response elicited by bacterial colonization in periodontal pockets, pocket epithelial cells not only serve as a barrier to isolate the pocket microenvironment from external stimuli but also regulate the functions of neighboring cells including fibroblasts and inflammatory cells. To elucidate this mechanism, we characterized the effects of periodontopathic bacterium Eikenella corrodens 1073 components on the production of someinflammatory mediators in a human oral epithelial cell line (KB). In enzyme-linked immunosorbent assay (ELISA), the E. corrodens supernatant induced interleukin-6 (IL-6), IL-8 and prostaglandin E-2 but not interferon-gamma (IFN-gamma) production by KB cells. After incubation with E. corrodens supernatant, YB cells showed a marked increase in the levels of IL-6, IL-8 and PG G/H synthase (cyclooxygenase)-2, but not IFN-gamma, gene expression by reverse-transcriptase polymerase chain reaction. All these E. corrodens products responsible for production of these inflammatory mediators resisted freezing and boiling and were present in a 10-kDa filtrate. These results imply that these soluble small-molecular-mass products from E. Corrodens stimulate various inflammatory mediator productions by human oral epithelial cells and may play a role in the initiation of periodontal inflammation and subsequently perpetuate the inflammatory response during chronic infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:49:21