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Titolo:
Tumor growth patterns and biological characteristics of early gastric carcinoma
Autore:
Maehara, Y; Kakeji, Y; Oda, S; Baba, H; Sugimachi, K;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ept Surg & Sci, Fukuoka 8128582, Japan
Titolo Testata:
ONCOLOGY
fascicolo: 2, volume: 61, anno: 2001,
pagine: 102 - 112
SICI:
0030-2414(2001)61:2<102:TGPABC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE P53; BONE-MARROW MICROMETASTASES; LYMPH-NODE METASTASIS; RAS GENE-MUTATIONS; HUMAN COLON-CANCER; PROGNOSTIC-SIGNIFICANCE; FACTOR EXPRESSION; DNA-PLOIDY; COLORECTAL-CANCER; SUPPRESSOR GENE;
Keywords:
early gastric cancer; growth pattern; prognosis; DNA ploidy; p53 overexpression; tumor angiogenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Maehara, Y Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Fukuoka 8128582, Japan
Citazione:
Y. Maehara et al., "Tumor growth patterns and biological characteristics of early gastric carcinoma", ONCOL-BASEL, 61(2), 2001, pp. 102-112

Abstract

Gastric cancer is a major malignant disease. The development of new diagnostic techniques and mass screening have led to increased detection rates ofpatients with early-stage gastric cancer in Japan. However, after curativeresection of early gastric cancer, there are various types of recurrences,and residual occult disease and distant micrometastasis precede death. Thegrowth and metastatic potential of cancer cells are closely related to thepostoperative outcome, and patients at risk for cancer-related death aftersurgery have to be closely monitored to prevent tumor recurrence. The biological behavior of cancer cells should be determined in patients with earlygastric cancer and with a less favorable prognosis to detect potential early recurrences in the liver. Two types of growth patterns have been found in early gastric cancer: the superficially spreading (Super) type and the penetrating (Pen) type, and the clinicopathological and biological characteristics of each type have been extensively determined. A subtype of the Pen-type gastric cancer, which is progressing expansively with complete destruction of the muscularis mucosae (Pen A type) has a less favorable prognosis due to early recurrences in the liver. These clinical cancer types are closely related to chromosomal instability in DNA aneuploidy and p53 overexpression, and vascular endothelial growth factor activation induced tumor angiogenesis, vascular invasion and hematogenous metastasis. Thus, patients with Pen-A-type cancer showing expansive tumor growth had a poorer postoperativeoutcome and a hematogenous-related recurrence of the cancer. Antiangiogenic approaches in a postoperative setting may prove to be effective in preventing tumor recurrence and improving the prognosis for these patients. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:32:33