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Titolo:
Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function
Autore:
Yu, WP; Pallen, CJ; Tay, A; Jirik, FR; Brenner, S; Tan, YH; Venkatesh, B;
Indirizzi:
Inst Mol & Cell Biol, Singapore 117609, Singapore Inst Mol & Cell Biol Singapore Singapore 117609 gapore 117609, Singapore Univ British Columbia, British Columbia Res Inst Childrens & Womens Hlth, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada Univ British Columbia Vancouver BC Canada V5Z 4H4 ver, BC V5Z 4H4, Canada
Titolo Testata:
ONCOGENE
fascicolo: 39, volume: 20, anno: 2001,
pagine: 5554 - 5561
SICI:
0950-9232(20010906)20:39<5554:CSBTFA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INOSITOL POLYPHOSPHATE PHOSPHATASE; PROTEIN-TYROSINE-PHOSPHATASE; TUMOR-SUPPRESSOR GENE; RILEY-RUVALCABA-SYNDROME; GERMLINE MUTATIONS; MOLECULAR-CLONING; FAMILY; REGION; BREAST; CANCER;
Keywords:
PTEN; phosphatase; tumor suppressor; Fugu;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Pallen, CJ Inst Mol & Cell Biol, 30 Med Dr, Singapore 117609, Singapore Inst Mol & Cell Biol 30 Med Dr Singapore Singapore 117609 pore
Citazione:
W.P. Yu et al., "Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function", ONCOGENE, 20(39), 2001, pp. 5554-5561

Abstract

Mutations of PTEN, which encodes a protein-tyrosine and lipid phosphatase,are prevalent in a variety of human cancers. The human genome 'draft' sequence still lacks organization and much of the PTEN and adjacent loci remainundefined. The pufferfish, Fugu rubripes, by virtue of having a compact genome represents an excellent template for rapid vertebrate gene discovery. Sequencing of 56 kb from the Fugu pten (fpten) locus identified four complete genes and one partial gene homologous to human genes. Genes neighboring fpten include a PAPS synthase (fpapss2) differentially expressed between non-metastatic/metastatic human carcinoma cell lines, an inositol phosphatase(fminpp1) and an omega class glutathione-S-transferase (fgsto). We have determined the order of human BAC clones at the hPTEN locus and that the locus contains hPAPSS2 and hMINPP1 genes oriented as are their Fugu orthologs. Although the human genes span 500 kb, the Fugu genes lie within only 22 kb due to the compressed intronic and intergenic regions that typify this genome. Interestingly, and providing striking evidence of regulatory element conservation between widely divergent vertebrate species, the compact 2.1 kb fpten promoter is active in human cells. Also, like hPTEN, fpten has a growth and tumor suppressor activity in human glioblastoma cells, demonstratingconservation of protein function.

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Documento generato il 04/07/20 alle ore 17:03:16