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Titolo:
Use of third generation gonadotropin-releasing hormone antagonists in in vitro fertilization-embryo transfer: A review
Autore:
Elter, K; Nelson, LR;
Indirizzi:
Univ Illinois, Dept Obstet & Gynecol, Coll Med, Div Reprod Endocrinol & Infertil, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 inol & Infertil, Chicago, IL 60612 USA
Titolo Testata:
OBSTETRICAL & GYNECOLOGICAL SURVEY
fascicolo: 9, volume: 56, anno: 2001,
pagine: 576 - 588
SICI:
0029-7828(200109)56:9<576:UOTGGH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN HYPERSTIMULATION SYNDROME; HUMAN MENOPAUSAL GONADOTROPIN; INTRACYTOPLASMIC SPERM INJECTION; HEALTHY FEMALE VOLUNTEERS; GANIRELIX ANTAGON/ORGALUTRAN-ASTERISK; LUTEINIZING-HORMONE; GNRH ANTAGONIST; ASSISTED REPRODUCTION; FOLLICULAR PHASE; LUTEAL-PHASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Nelson, LR Univ Illinois, Dept Obstet & Gynecol, Coll Med, Div Reprod Endocrinol & Infertil, 820 S Wood St, Chicago, IL 60612 USA Univ Illinois 820 SWood St Chicago IL USA 60612 , IL 60612 USA
Citazione:
K. Elter e L.R. Nelson, "Use of third generation gonadotropin-releasing hormone antagonists in in vitro fertilization-embryo transfer: A review", OB GYN SURV, 56(9), 2001, pp. 576-588

Abstract

Before gonadotropin-releasing hormone agonists (GnRHa) became available, approximately 20% of stimulated cycles within an in vitro fertilization (IVF) program were cancelled due to premature LH surges. By using the GnRHa to prevent LH surges via gonadotrope GnRH receptor downregulation and desensitization, this percentage decreased to about 2%, and concomitantly, the IVF and pregnancy rates per cycle initiated were increased. Several treatment schedules currently are in use, including the so-called "long protocol," in which the GnRHa is begun in the luteal phase and down-regulation occurs before the start of the gonadotropin-stimulation treatment phase. This is generally the most effective regimen and is presently the most frequently used protocol. However, it has some disadvantages, such as hypoestrogenic side effects and an increase in the number of ampules of FSH or hMG required for adequate stimulation. There is a new generation of GnRH antagonists now clinically available, that has been able to minimize the potential side effects and provide reliable antagonism at the GnRH receptor. These agents seem better suited than GnRHa for assisted reproductive technology (ART) cycles inasmuch as they can prevent LH surges without requiring complete gonadotropin suppression. We have reviewed the current literature concerning their use in IVF cycles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:52:16