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Titolo:
IDENTIFICATION OF A LEADER EXON AND A CORE PROMOTER FOR THE RAT TUBEROUS SCLEROSIS-2 (TSC2) GENE AND STRUCTURAL COMPARISON WITH THE HUMAN HOMOLOG
Autore:
KOBAYASHI T; URAKAMI S; CHEADLE JP; ASPINWALL R; HARRIS P; SAMPSON JR; HINO O;
Indirizzi:
INST CANC RES,DEPT EXPT PATHOL,TOSHIMA KU,1-37-1 KAMI IKEBUKURO TOKYO170 JAPAN INST CANC RES,DEPT EXPT PATHOL,TOSHIMA KU TOKYO 170 JAPAN UNIV WALES COLL MED,INST MED GENET CARDIFF CF4 4XN S GLAM WALES JOHN RADCLIFFE HOSP,INST MOL MED OXFORD OX3 9DU ENGLAND
Titolo Testata:
Mammalian genome
fascicolo: 8, volume: 8, anno: 1997,
pagine: 554 - 558
SICI:
0938-8990(1997)8:8<554:IOALEA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOMINANTLY INHERITED CANCER; EKER RAT; PREDISPOSING GENE; MESSENGER-RNA; MODEL; SITES; HETEROZYGOSITY; TISSUES; LOCUS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
T. Kobayashi et al., "IDENTIFICATION OF A LEADER EXON AND A CORE PROMOTER FOR THE RAT TUBEROUS SCLEROSIS-2 (TSC2) GENE AND STRUCTURAL COMPARISON WITH THE HUMAN HOMOLOG", Mammalian genome, 8(8), 1997, pp. 554-558

Abstract

Hereditary renal carcinoma in the Eker rat is an excellent example ofpredisposition to a specific cancer being transmitted as a dominant trait. Recently, we identified a germline mutation of the tuberous sclerosis 2 (Tsc2) gene in the Eker rat. In the present study, we analyzedthe upstream region of the Tsc2 gene. A novel leader exon (exon 1a) in a CpG island was found, and core promoter activity was identified ina 242-bp region of this island. Exon 1a and the promoter region were conserved in the human TSC2 gene. In addition, a rat homolog of a genefound upstream of TSC2 in human has been identified, indicating that the genomic organization around Tsc2/TSC2 is conserved between the twospecies. Characterization of the 5' region of Tsc2 and TSC2 will facilitate studies of the regulation of the gene and its disregulation in tumorigenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 14:44:51