Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tau accumulation in a patient with pallidonigroluysian atrophy
Autore:
Mori, H; Motoi, Y; Kobayashi, T; Hasegawa, M; Yamamura, A; Iwatsubo, T; Mizuno, Y;
Indirizzi:
Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 eurol, Bunkyo Ku, Tokyo 1138421, Japan Tokyo Inst Psychiat, Dept Mol Neurobiol, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 Neurobiol, Tokyo 1568585, Japan Juntendo Univ, Sch Med, Dept Pathol, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 Med, Dept Pathol, Tokyo 1138421, Japan Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Neuropathol & Neurosci, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ropathol & Neurosci, Tokyo 1130033, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 309, anno: 2001,
pagine: 89 - 92
SICI:
0304-3940(20010824)309:2<89:TAIAPW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; PAIRED HELICAL FILAMENTS; CORTICOBASAL DEGENERATION; MONOCLONAL-ANTIBODY; ALZHEIMERS-DISEASE; PHOSPHORYLATION; PROTEIN; ISOFORMS; GENE;
Keywords:
pallidonigroluysian atrophy; tau; tauopathy; progressive supranuclear palsy; corticobasal degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Mori, H Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, 2-1-1 Hongo, Tokyo1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 okyo 1138421, Japan
Citazione:
H. Mori et al., "Tau accumulation in a patient with pallidonigroluysian atrophy", NEUROSCI L, 309(2), 2001, pp. 89-92

Abstract

We studied the brain of a patient with pallidonigroluysian atrophy (PNLA) in whom argyrophilic and abnormally phosphorylated tau positive neurons andglia were identified in the brain on Gallyas-Braak silver staining and immunohistochemical analysis although neurofibrillary tangles were not seen byBodian silver stain. Immunohistochemical studies using six anti-tau antibodies that recognize the different phosphorylated epitopes of tau protein revealed that these epitopes in neurons and glial cells share common characteristics with neurofibrillary tangles in Alzheimer's disease. Immunoblot analysis of phosphorylated tau protein showed major bands of 64 and 68 kDa andafter dephosphorylation, tau consisted mainly of 4 repeat tau. No mutations were detected in the coding exons and their flanking intronic regions of the tau gene. This study suggests that PNLA is one of tauopathy and the biochemical characteristics of phosphorylated tau are similar to those found in progressive supranuclear palsy and corticobasal degeneration. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:26:35