Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chronic loss of ovarian function decreases transport of leptin into mouse brain
Autore:
Kastin, AJ; Akerstrom, V; Maness, LM;
Indirizzi:
Vet Affairs Med Ctr, New Orleans, LA 70112 USA Vet Affairs Med Ctr New Orleans LA USA 70112 r, New Orleans, LA 70112 USA Tulane Univ, Sch Med, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 , Sch Med, New Orleans, LA 70112 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 310, anno: 2001,
pagine: 69 - 71
SICI:
0304-3940(20010907)310:1<69:CLOOFD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; POSTMENOPAUSAL WOMEN; FAT DISTRIBUTION; BODY-COMPOSITION; OBESE MICE; RATS; MENOPAUSE; THERAPY; TERM; RECEPTOR;
Keywords:
obesity; leptin; ovary; menopause; blood-brain barrier; polypeptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kastin, AJ Vet Affairs Med Ctr, 1601 Perdido St, New Orleans, LA 70112 USAVet Affairs Med Ctr 1601 Perdido St New Orleans LA USA 70112 SA
Citazione:
A.J. Kastin et al., "Chronic loss of ovarian function decreases transport of leptin into mouse brain", NEUROSCI L, 310(1), 2001, pp. 69-71

Abstract

Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression analysis, a sensitive technique for quantifying blood-to-brain transport of peptides and polypeptides, we found that mice ovariectomized for at least 5 weeks had markedly reduced entry of the satiety factor leptin into brain. The rate of entry of leptin into brain remained reduced half a year later. The results suggest that the weight gain resulting from loss of ovarian function could be explained by decreased transport of leptin into the brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:33:10