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Titolo:
Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat
Autore:
Amara, DA; Segu, L; Buhot, MC;
Indirizzi:
Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5106, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 UMR 5106, F-33405 Talence, France INSERM, Steroides & Syst Nerveux U488, F-94276 Le Kremlin Bicetre, France INSERM Le Kremlin Bicetre France F-94276 4276 Le Kremlin Bicetre, France
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 310, anno: 2001,
pagine: 25 - 28
SICI:
0304-3940(20010907)310:1<25:RDI5A5>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; RECEPTORS; BRAIN; SEROTONIN; LOCALIZATION; SUBICULUM; TERMINALS; CORTEX;
Keywords:
5-HT1A; 5-HT1B; subiculum; hippocampus; CA1; autoradiography; ibotenic acid lesion; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Buhot, MC Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5106, Ave Fac, F-33405 Talence, France Univ Bordeaux 1 Ave Fac Talence France F-33405 Talence, France
Citazione:
D.A. Amara et al., "Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat", NEUROSCI L, 310(1), 2001, pp. 25-28

Abstract

The cellular location of 5-HT1A and 5-HT1B binding sites in the hippocampus was investigated using a stereotaxic unilateral lesion of the CA1 field by ibotenic acid, followed by autoradiography on brain sections with the specific ligands [H-3]8-OH-DPAT and S-CM-G[I-125]TNH2, respectively. As compared to the contralateral side of the lesion, the ipsilateral side exhibited a decrease in the density of 5-HT1A binding sites in the strata oriens and radiatum of CA1, and of 5-HT1B binding sites in the dorsal subiculum and stratum oriens of CA1. The results demonstrate that 5-HT1A binding sites are located on dendrites whereas 5-HT1B binding sites are located on axon terminals of CA1 pyramidal cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:35:25