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Titolo:
A region of the rat N-methyl-D-aspartate receptor 2A subunit that is sufficient for potentiation by phorbol esters
Autore:
Grant, ER; Guttmann, RP; Seifert, KM; Lynch, DR;
Indirizzi:
Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Neurol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Pediat, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 310, anno: 2001,
pagine: 9 - 12
SICI:
0304-3940(20010907)310:1<9:AROTRN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; NMDA RECEPTORS; PHOSPHORYLATION; INHIBITION; MODULATION; CHANNEL; BINDING; SITES;
Keywords:
N-methyl-D-aspartate; protein kinase C; calcium; phorbol ester;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lynch, DR Childrens Hosp Philadelphia, Dept Neurosci Res, 502 Abramson Bldg, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia 502 Abramson BldgPhiladelphia PA USA 19104
Citazione:
E.R. Grant et al., "A region of the rat N-methyl-D-aspartate receptor 2A subunit that is sufficient for potentiation by phorbol esters", NEUROSCI L, 310(1), 2001, pp. 9-12

Abstract

N-methyl-D-aspartate (NMDA) receptors are modulated by protein kinase C (PKC) in vivo and in heterologous expression systems. In heterologous expression systems, PKC-mediated modulation is subunit specific with NR2A-containing receptors being potentiated by phorbol 12-myristate 13-acetate (PMA), while NR2C-containing receptors are inhibited or unaffected. In the present study we have produced chimeric receptors containing NR2A and NR2C to definethe components of NR2A which are sufficient for potentiation by PMA. Aminoacids 1105-1400 of NR2A placed onto the C-terminus of NR2C at amino acid 1102 was the minimum region sufficient for producing a PMA-stimulated receptor. This suggests that this region contains structural determinants for PKC-mediated potentiation of NR2A receptors. (C) 2001 Published by Elsevier Science Ireland Ltd.

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Documento generato il 05/04/20 alle ore 09:38:36