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Titolo:
Gene expression profiling of the tau mutant (P301L) transgenic mouse brain
Autore:
Ho, L; Xiang, ZM; Mukherjee, P; Zhang, W; De Jesus, N; Mirjany, M; Yemul, S; Pasinetti, GM;
Indirizzi:
Mt Sinai Sch Med, Dept Psychiat, Neuroinflammat Res Ctr, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 at Res Ctr, New York, NY 10029 USA Mt Sinai Sch Med, Inst Computat Biomed, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 tat Biomed, New York, NY 10029 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 310, anno: 2001,
pagine: 1 - 4
SICI:
0304-3940(20010907)310:1<1:GEPOTT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA TRANSPORT; STAUFEN PROTEIN; APOPTOSIS; ADRENOMEDULLIN; TRAFFICKING; INVOLVEMENT; CLONING; CELLS;
Keywords:
tauopathy; microarray; apoptosis; frontotemporal dementia and parkinsonism; neurodegeneration; transgenics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Pasinetti, GM Mt Sinai Sch Med, Dept Psychiat, Neuroinflammat Res Ctr, 1 Gustave L Levy Pl, New York, NY 10029 USA Mt Sinai Sch Med 1 Gustave L Levy Pl New York NY USA 10029 A
Citazione:
L. Ho et al., "Gene expression profiling of the tau mutant (P301L) transgenic mouse brain", NEUROSCI L, 310(1), 2001, pp. 1-4

Abstract

To provide a global analysis of the influence of Tau neuropathology at molecular level, we used cDNA arrays representing 8832 genes to determine the mRNA expression profile in transgenic mice expressing the most common frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) Tau mutation (P301L) (Nat. Genet. (2000) 402). Genes whose expression is associated with development of neurofibrillary tangles and neuron loss in P301L mice with motor and behavioral deficits were identified. The data suggest that a major mechanism underlying P301LTau neurodegeneration primarily involved altered expression of genes contributing to inhibition of apoptosis and intracellular transport. We propose that the expression of mutated P301L maylead to select altered expression of genes which may cause neurodegeneration in FTDP-17. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:42:38