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Titolo:
Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze
Autore:
Nava, F; Carta, G; Colombo, G; Gessa, GL;
Indirizzi:
Univ Cagliari, Dept Neurosci Bernard B Brodie, I-09042 Cagliari, Italy Univ Cagliari Cagliari Italy I-09042 d B Brodie, I-09042 Cagliari, Italy Neurosci SCARL, Cagliari, Italy Neurosci SCARL Cagliari ItalyNeurosci SCARL, Cagliari, Italy
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 3, volume: 41, anno: 2001,
pagine: 392 - 399
SICI:
0028-3908(200109)41:3<392:EOCDTO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL-PREFRONTAL CORTEX; IMPAIRS SPATIAL MEMORY; CANNABINOID CB1; DOPAMINE NEURONS; RAT-BRAIN; RECEPTOR ANTAGONIST; SQUIRREL-MONKEYS; SR 141716A; MARIJUANA; RELEASE;
Keywords:
cannabinoids; microdialysis; T-maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Nava, F Univ Cagliari, Dept Neurosci Bernard B Brodie, Cittadella Univ Monserrato,SS 554 Km 4-500, I-09042 Cagliari, Italy Univ Cagliari Cittadella Univ Monserrato,SS 554 Km 4-500 Cagliari Italy I-09042
Citazione:
F. Nava et al., "Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze", NEUROPHARM, 41(3), 2001, pp. 392-399

Abstract

Delta (9)-Tetrahydrocannabinol (Delta (9)-THC), the psychoactive ingredient of cannabis sativa, reduces both extracellular hippocampal acetylcholine concentration and correct alternation tasks in the T-maze. The principal aim of this study was to determine whether a chronic Delta (9)-THC treatment would induce tolerance both to the reduction of extracellular hippocampal acetylcholine concentration and memory deficit produced by the drug. Our results show that a chronic Delta (9)-THC treatment (5 mg/kg, i.p., twice daily for two weeks) did not produce tolerance to the inhibitory effects induced by the drug. Moreover, no strict temporal correlation between thetwo Delta (9)-THC effects was observed: the inhibition in extracellular acetylcholine concentration appeared only 80 min after treatment, while the reduction of correct alternation tasks in the T-maze began after 20 min. Thecognitive and cholinergic effects induced by a chronic Delta (9)-THC treatment were completely blocked by the CB1 cannabinoid receptor antagonist SR 141716A, indicating an involvement of CB1 cannabinoid receptors in the persistent negative effects induced by the drug. These findings confirm the proposition that CB1 cannabinoid receptors mediate the negative effects induced by Delta (9)-THC both on hippocampal extracellular acetylcholine concentration and correct alternation tasks in the T-maze, and they indicate that these effects may be differentiated. However,the major outcome of this work is the demonstration that no tolerance to the two inhibitory effects develops after a chronic Delta (9)-THC treatment. (C) 2001 Published by Elsevier Science Ltd.

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Documento generato il 01/04/20 alle ore 11:23:07