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Titolo:
Effect of levetiracetam on human corticospinal excitability
Autore:
Sohn, YH; Kaelin-Lang, A; Jung, HY; Hallett, M;
Indirizzi:
NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 tor Control Sect, NIH, Bethesda, MD 20892 USA NINDS, Human Cort Physiol Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 ort Physiol Sect, NIH, Bethesda, MD 20892 USA Yonsei Univ, Coll Med, Dept Neurol, Seoul, South Korea Yonsei Univ SeoulSouth Korea Coll Med, Dept Neurol, Seoul, South Korea Yonsei Univ, Coll Med, Brain Res Inst, Seoul, South Korea Yonsei Univ Seoul South Korea l Med, Brain Res Inst, Seoul, South Korea
Titolo Testata:
NEUROLOGY
fascicolo: 5, volume: 57, anno: 2001,
pagine: 858 - 863
SICI:
0028-3878(20010911)57:5<858:EOLOHC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; REFRACTORY PARTIAL SEIZURES; STATISTICAL PROCESS-CONTROL; UCB L059; ANTIEPILEPTIC DRUGS; DOUBLE-BLIND; ANTICONVULSANT LEVETIRACETAM; CORTICAL EXCITABILITY; SILENT PERIOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hallett, M NINDS, Human Motor Control Sect, NIH, Bldg 10,Rm 5N226,10 Ctr Dr,MSC 1428,Bethesda, MD 20892 USA NINDS Bldg 10,Rm 5N226,10 Ctr Dr,MSC 1428Bethesda MD USA 20892
Citazione:
Y.H. Sohn et al., "Effect of levetiracetam on human corticospinal excitability", NEUROLOGY, 57(5), 2001, pp. 858-863

Abstract

Objective: To investigate whether levetiracetam. (LTC) alters corticospinal excitability in humans. Background: Although the antiepileptic activity of LTC is well recognized, its mechanism of action has yet to be determined. Transcranial magnetic stimulation (TMS) has been used to investigate the pharmacologic effects of various antiepileptic drugs on human corticospinal excitability. Methods: The authors performed TMS before and after double-blind administration of 3000 mg LTC or placebo in six healthy volunteers. TMSmeasurements included resting and active motor threshold (MT), recruitmentcurve of motor-evoked potential amplitudes, intracortical inhibition, and facilitation using the paired-pulse technique and silent period. F-wave andcompound muscle action potential (CMAP) were also measured. Results: In recruitment curve measurements, motor-evoked potential amplitude was reduced for LTC with high stimulation intensity (130% and 140% of resting MT) compared with placebo (p < 0.05 and p < 0.01), but not with relatively low stimulation intensity (110% and 120%). The changes in other TMS measurements as well as F-wave and CHAP after LTC did not differ significantly from those observed after placebo administration. Conclusion: These results suggest that LTC reduces the corticospinal neuronal response to magnetic stimulation, preferentially affecting less excitable neurons. The lack of change in F-wave and CHAP suggests that this effect is mainly derived from the motor cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 09:36:33