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Titolo:
Oral supplementation of branched-chain amino acid improves nutritional status in elderly patients on chronic haemodialysis
Autore:
Hiroshige, K; Sonta, T; Suda, T; Kanegae, K; Ohtani, A;
Indirizzi:
Social Insurance Chikuho Hosp, Div Renal, Nougata City, Fukuoka 8220034, Japan Social Insurance Chikuho Hosp Nougata City Fukuoka Japan 8220034 4, Japan
Titolo Testata:
NEPHROLOGY DIALYSIS TRANSPLANTATION
fascicolo: 9, volume: 16, anno: 2001,
pagine: 1856 - 1862
SICI:
0931-0509(200109)16:9<1856:OSOBAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRADIALYTIC PARENTERAL-NUTRITION; HEMODIALYSIS-PATIENTS; MORTALITY; DISEASE; UREMIA;
Keywords:
branched-chain amino acids; dietary intake; elderly patient; haemodialysis; nutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hiroshige, K Social Insurance Chikuho Hosp, Div Renal, 765-1 Yamabe, Nougata City, Fukuoka 8220034, Japan Social Insurance Chikuho Hosp 765-1 Yamabe Nougata City Fukuoka Japan 8220034
Citazione:
K. Hiroshige et al., "Oral supplementation of branched-chain amino acid improves nutritional status in elderly patients on chronic haemodialysis", NEPH DIAL T, 16(9), 2001, pp. 1856-1862

Abstract

Background. Anorexia may be associated with decreased plasma levels of branched-chain amino acids (BCAA). In malnourished elderly haemodialysis (HD) patients, oral BCAA supplementation may improve anorexia, resulting in improved nutritional status. Methods. Among 44 elderly (age > 70 years) patients on chronic HD, 28 patients with low plasma albumin concentration (<3.5 g/dl) were classified as the malnourished group; they also suffered from anorexia. The other 16 patients did not complain of anorexia and were classified as the welt-nourished group. We performed a 12-month, placebo-controlled, double-blind study on the malnourished group. Fourteen patients each received daily oral BCAA supplementation (12 g/day) or a placebo: in random order in a crossover trial for 6 months. Body fat percentage, lean body mass, plasma albumin concentration, dietary protein and caloric intakes, and plasma amino acid profiles were monitored. Results. Lower plasma levels of BCAA and lower protein and caloric intakeswere found in the malnourished group as compared to the well-nourished group. In BCAA-treated malnourished patients, anorexia and poor oral protein and caloric intakes improved within a month concomitant with the improvementin plasma BCAA levels over the values in well-nourished patients. After 6 months of BCAA supplementation, anthropometric indices showed a statistically significant increase and mean plasma albumin concentration increased from 3.31 g/dl to 3.93 g/dl. After exchanging BCAA for a placebo, spontaneous oral food intake decreased, but the favourable nutritional status persistedfor the next 6 months. In 14 patients initially treated with a placebo, nosignificant changes in nutritional parameters were observed during the first 6 months. However, positive results were obtained by BCAA supplementation during the subsequent 6 months, and mean plasma albumin concentration increased from 3.27 g/dl to 3.81 g/dl. Conclusions. Normalization of low plasma levels of BCAA by oral supplementation can reduce anorexia and significantly improve overall nutritional status in elderly malnourished HD patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:53:12