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Titolo:
Transcriptional channelopathies: An emerging class of disorders
Autore:
Waxman, SG;
Indirizzi:
Yale Univ, Sch Med, Dept Neurol LCI 707, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Neurol LCI 707, New Haven, CT 06520 USA
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 9, volume: 2, anno: 2001,
pagine: 652 - 659
SICI:
1471-0048(200109)2:9<652:TCAECO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROOT GANGLION NEURONS; SPINAL SENSORY NEURONS; NERVE GROWTH-FACTOR; SODIUM-CHANNEL EXPRESSION; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CUTANEOUS AFFERENT NEURONS; CEREBELLAR PURKINJE-CELLS; SUBUNIT MESSENGER-RNAS; GATED NA CHANNEL; MULTIPLE-SCLEROSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Waxman, SG Yale Univ, Sch Med, Dept Neurol LCI 707, POB 208018,333 Cedar St, New Haven, CT 06520 USA Yale Univ POB 208018,333 Cedar St New Haven CT USA 06520 20 USA
Citazione:
S.G. Waxman, "Transcriptional channelopathies: An emerging class of disorders", NAT REV NEU, 2(9), 2001, pp. 652-659

Abstract

Two types of channelopathy are now well recognized: genetic, in which ion channels function abnormally or fail to function as a result of mutations, and autoimmune, in which antibodies perturb channel function. Recent studies have provided growing evidence for the existence of a third type-transcriptional channelopathies-which result from changes in the expression of non-mutated channel genes. A well-studied example is peripheral nerve injury, which causes spinal sensory neurons to turn off some active sodium channel genes and turn on others that were previously silent, a set of changes that can result in hyperexcitability of these cells. Recent studies have also shown upregulated expression of sensory-neuron-specific sodium channels in Purkinje cells, indicating that a transcriptional channelopathy might perturbcerebellar function in multiple sclerosis. It is probable that we will soon recognize further disorders that are characterized by dysregulation of channel gene expression in neurons. A better understanding of transcriptionalchannelopathies might provide us with new opportunities to treat these disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:14:00