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Titolo:
Glutamate release promotes growth of malignant gliomas
Autore:
Takano, T; Lin, JHC; Arcuino, G; Gao, Q; Yang, J; Nedergaard, M;
Indirizzi:
New York Med Coll, Dept Cell Biol Anat & Pathol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 & Pathol, Valhalla, NY 10595 USA Univ Rochester, Med Ctr, Dept Anesthesiol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 nesthesiol, Rochester, NY 14642 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 9, volume: 7, anno: 2001,
pagine: 1010 - 1015
SICI:
1078-8956(200109)7:9<1010:GRPGOM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONIST; EXTRACELLULAR GLUTAMATE; CELLS; ASTROCYTES; TRANSPORTERS; RATS; EXCITOTOXICITY; NEUROTOXICITY; EXPRESSION; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nedergaard, M New York Med Coll, Dept Cell Biol Anat & Pathol, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 halla, NY 10595 USA
Citazione:
T. Takano et al., "Glutamate release promotes growth of malignant gliomas", NAT MED, 7(9), 2001, pp. 1010-1015

Abstract

Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and neurodegenerative diseases. Although recent data show thatcultured glioma cells secrete glutamate, the growth potential of brain tumors has not yet been linked to an excitotoxic mechanism. Using bioluminescence detection of glutamate release from freshly prepared brain slices, we show that implanted glioma cells continue to secrete glutamate. Moreover, gliomas with high glutamate release have a distinct growth advantage in host brain that is not present in vitro. Treatment with the NMDA receptor antagonists MK801 or memantine slowed the growth of glutamate-secreting tumors insitu, suggesting that activation of NMDA receptors facilitates tumor expansion. These findings support a new approach for therapy of brain tumors, based upon antagonizing glutamate secretion or its target receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:10:26