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Titolo:
Regulatory T cells in the control of immune pathology
Autore:
Maloy, KJ; Powrie, F;
Indirizzi:
Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England Univ Oxford Oxford England OX1 3RE n Sch Pathol, Oxford OX1 3RE, England
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 9, volume: 2, anno: 2001,
pagine: 816 - 822
SICI:
1529-2908(200109)2:9<816:RTCITC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL SELF-TOLERANCE; ANTIGEN-PRESENTING CELLS; GROWTH-FACTOR-BETA; SPONTANEOUS AUTOIMMUNE ENCEPHALOMYELITIS; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; DENDRITIC CELLS; IN-VIVO; TGF-BETA; INTESTINAL INFLAMMATION; EFFECTOR FUNCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Powrie, F Univ Oxford, Sir William Dunn Sch Pathol, S Parks Rd, Oxford OX13RE, England Univ Oxford S Parks Rd Oxford England OX1 3RE OX1 3RE, England
Citazione:
K.J. Maloy e F. Powrie, "Regulatory T cells in the control of immune pathology", NAT IMMUNOL, 2(9), 2001, pp. 816-822

Abstract

It is now well established that regulatory T (T-R) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T-R cell biology remain unresolved, especiallywith regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T-R cellsmay inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T-R cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:08:48