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Titolo:
Differential effects of forskolin and phobol 12-myristate-13-acetate on the c-fos and c-jun mRNA expression in rat C6 glioma cells
Autore:
Lee, JK; Won, JS; Choi, MR; Kim, YH; Suh, HW;
Indirizzi:
Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 200702, South Korea HallymUniv Chunchon South Korea 200702 ol, Chunchon 200702, South Korea Hallym Univ, Coll Med, Inst Nat Med, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 ed, Chunchon 200702, South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 1, volume: 12, anno: 2001,
pagine: 11 - 16
SICI:
1016-8478(20010831)12:1<11:DEOFAP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROENKEPHALIN MESSENGER-RNA; TRANSCRIPTION FACTOR AP-1; IMMEDIATE-EARLY GENES; PROTEIN-KINASE-C; GLUCOCORTICOID RECEPTOR; BINDING PROTEIN; DOWN-REGULATION; NERVOUS-SYSTEM; ASTROCYTES; ACTIVATION;
Keywords:
c-fos proto-oncogene; c-jun proto-oncogene; glucocorticoid; protein kinase A; protein kinase C; rat C6 glioma cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Suh, HW Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 chon 200702, South Korea
Citazione:
J.K. Lee et al., "Differential effects of forskolin and phobol 12-myristate-13-acetate on the c-fos and c-jun mRNA expression in rat C6 glioma cells", MOL CELLS, 12(1), 2001, pp. 11-16

Abstract

The effects of forskolin (FSK) and phobol 12-myristate-13-acetate (PMA) onc-fos and c-jun mRNA expressions in rat C6 glioma cells were studied. BothFSK and PMA increased the c-fos mRNA level. The C-jun mRNA level was decreased by FSK, whereas it was increased by PMA. The elevated c-fos mRNA level, induced by FSK or PMA, was significantly inhibited by dexamethasone (DEX). In contrast, DEX did not affect the FSK- and PMA-induced response of the c-jun mRNA level. Cycloheximide (CHX) caused a superinduction of the FSK- or PMA-induced c-fos mRNA level. Furthermore, CHX also potentiated the PMA-induced c-jun mRNA level. However, CHX did not affect the FSK-induced down-regulation of the c-jun mRNA level. When C6 glioma cells were incubated withPMA and FSK, the PMA-induced c-jun mRNA level was inhibited by FSK, whereas FSK did not affect the PMA-induced c-fos mRNA level. Our results suggest that the activations of PKA and PKC pathways have different roles in the regulation of the e-jun mRNA expression in rat C6 glioma cells. PKA activation can inhibit induction of the c-jun mRNA expression by PMA. In addition, DEX appears to have a selective inhibitory action against e-fos, but not c-jun, mRNA expression that is regulated by PKA and PKC. On-going protein synthesis inhibition is required for the superinduction of the c-fos expressionthat is induced by PMA, or FSK and the PMA-induced e-jun mRNA level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:43:39