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Titolo:
Nuclear mRNA binding proteins couple pre-mRNA splicing and post-splicing events
Autore:
Kim, VN; Dreyfuss, G;
Indirizzi:
Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Med Inst, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Biophys, Philadelphia, PA 19104 USA Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 Sci, Seoul 151742, South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 1, volume: 12, anno: 2001,
pagine: 1 - 10
SICI:
1016-8478(20010831)12:1<1:NMBPCP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPORT; CONSTITUTIVE TRANSPORT ELEMENT; TRANSLATIONAL TERMINATION CODON; OPEN READING FRAME; NONSENSE CODONS; SACCHAROMYCES-CEREVISIAE; POLY(A)(+) RNA; DECAY PATHWAY; HUMAN HOMOLOG; UPF1 PROTEIN;
Keywords:
Aly; DEK; exon-exon junction; mRNA; NMD; nuclear export; RNA binding protein; RNPS1; splicing; SRm160; Upf; Y14;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Dreyfuss, G Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 hiladelphia, PA 19104 USA
Citazione:
V.N. Kim e G. Dreyfuss, "Nuclear mRNA binding proteins couple pre-mRNA splicing and post-splicing events", MOL CELLS, 12(1), 2001, pp. 1-10

Abstract

New information about the pathway of eukaryotic gene expression indicates that many of the steps in this pathway are functionally interconnected. An important link has recently emerged between pre-mRNA splicing and the post-splicing events such as mRNA export and mRNA decay. Recent results reveal that the coupling is mediated by a novel group of nuclear mRNA-binding proteins that are recruited to the mRNAs by spliceosome. These proteins, including Y14, Aly/REF, RNPS1, SRm160, and DEK, are assembled into a stable complex near exon-exon junctions of spliced mRNAs. Several of them persist in their attachment to mRNAs in the cytoplasm thus communicating the history of splicing to the downstream events. The detailed mechanism of coupling and the factors that mediate these processes remain to be determined in the coming years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 01:05:26