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Titolo:
Convergence of two global transcriptional regulators on nitrogen inductionof the stress-acclimation gene nblA in the cyanobacterium Synechococcus spPCC 7942
Autore:
Luque, I; Zabulon, G; Contreras, A; Houmard, J;
Indirizzi:
Ecole Normale Super, CNRS, UMR 8543, F-75230 Paris 05, France Ecole Normale Super Paris France 05 , UMR 8543, F-75230 Paris 05, France Univ Alicante, Fac Ciencias, Div Genet, E-03080 Alicante, Spain Univ Alicante Alicante Spain E-03080 Div Genet, E-03080 Alicante, Spain
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 4, volume: 41, anno: 2001,
pagine: 937 - 947
SICI:
0950-382X(200108)41:4<937:COTGTR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SP STRAIN PCC-7942; ANABAENA SP; GLUTAMINE-SYNTHETASE; HETEROCYST DEVELOPMENT; ANACYSTIS-NIDULANS; NTCA-BINDING; IDENTIFICATION; ASSIMILATION; DEGRADATION; PCC-7120;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Luque, I Ecole Normale Super, CNRS, UMR 8543, 46 Rue Ulm, F-75230 Paris 05, France Ecole Normale Super 46 Rue Ulm Paris France 05 Paris 05, France
Citazione:
I. Luque et al., "Convergence of two global transcriptional regulators on nitrogen inductionof the stress-acclimation gene nblA in the cyanobacterium Synechococcus spPCC 7942", MOL MICROB, 41(4), 2001, pp. 937-947

Abstract

Cyanobacteria respond to environmental stress conditions by degrading their phycobilisomes, the light harvesting complexes for photosynthesis. The expression of nblA, a key gene in this process, is controlled by the responseregulator NbIR in Synechococcus sp. PCC 7942. Here we show that, under nitrogen stress, nblA is also regulated by NtcA, the global regulator for nitrogen control. NtcA activation of nblA was found to be nitrogen-specific anddid not take place under sulphur stress. Transcripts from the two major transcription start points (tsp) for the nblA gene were induced in response to nitrogen and sulphur starvation. The most active one (tspII) required both NbIR and NtcA to induce full nblA expression under nitrogen starvation. NbIR and NtcA bound in vitro to a DNA fragment from the nblA promoter region, suggesting that, under nitrogen stress, both NbIR and NtcA activate the main regulated promoter (PnblA-2) by direct DNA-binding. The structure of PnblA-2 differs from that of the canonical NtcA-activated promoter and it is therefore proposed to represent a novel type of NtcA-dependent promoter. Weanalysed expression patterns from ntcA and selected NtcA targets in NtcA(-), NbIR- and wild-type strains, and discuss data suggesting further interrelations between phycobilisome degradation and nitrogen assimilation regulatory pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:25:35