Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Structure of the catalytic core of S-cerevisiae DNA polymerase eta: Implications for translesion DNA synthesis
Autore:
Trincao, J; Johnson, RE; Escalante, CR; Prakash, S; Prakash, L; Aggarwal, AK;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Phys & Biophys, Struct Biol Program, New York,NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 rogram, New York,NY 10029 USA Univ Texas, Med Branch, Sealy Ctr Mol Sci, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 ly Ctr Mol Sci, Galveston, TX 77555 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 2, volume: 8, anno: 2001,
pagine: 417 - 426
SICI:
1097-2765(200108)8:2<417:SOTCCO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMINE-THYMINE DIMER; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; XERODERMA-PIGMENTOSUM; LARGE FRAGMENT; GENE ENCODES; TERNARY COMPLEXES; KLENOW FRAGMENT; REPLICATION; BYPASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Aggarwal, AK CUNY Mt Sinai Sch Med, Dept Phys & Biophys, Struct Biol Program, New York,NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 ork,NY 10029 USA
Citazione:
J. Trincao et al., "Structure of the catalytic core of S-cerevisiae DNA polymerase eta: Implications for translesion DNA synthesis", MOL CELL, 8(2), 2001, pp. 417-426

Abstract

DNA polymerase eta is unique among eukaryotic polymerases in its proficient ability to replicate through a variety of distorting DNA lesions. We report here the crystal structure of the catalytic core of S. cerevisiae DNA polymerase eta, determined at 2.25 Angstrom resolution. The structure revealsa novel polydactyl right hand shaped molecule with a unique polymerase-associated domain. We identify the catalytic residues and show that the fingers and thumb domains are unusually small and stubby. In particular, the unexpected absence of helices "O" and "O1" in the fingers domain suggests that openness of the active site is the critical feature which enables DNA polymerase eta to replicate through DNA lesions such as a UV-induced cis-syn thymine-thymine dimer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:09:34