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Titolo:
Mitochondrial defects in neurodegenerative disease
Autore:
Wallace, DC;
Indirizzi:
Emory Univ, Sch Med, Ctr Mol Med, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 h Med, Ctr Mol Med, Atlanta, GA 30322 USA
Titolo Testata:
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 158 - 166
SICI:
1080-4013(2001)7:3<158:MDIND>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEREDITARY OPTIC NEUROPATHY; CYTOCHROME-C-OXIDASE; ADENINE-NUCLEOTIDE TRANSLOCATOR; MARROW-PANCREAS SYNDROME; HUMAN SKELETAL-MUSCLE; SUBACUTE NECROTIZING ENCEPHALOPATHY; MANGANESE SUPEROXIDE-DISMUTASE; RESPIRATORY-CHAIN FUNCTION; GENE-EXPRESSION PROFILE; LARGE RIBOSOMAL-RNA;
Keywords:
mitochondrial DNA; apoptosis; radical oxygen species; mutations; aging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
153
Recensione:
Indirizzi per estratti:
Indirizzo: Wallace, DC Emory Univ, Sch Med, Ctr Mol Med, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ol Med, Atlanta, GA 30322 USA
Citazione:
D.C. Wallace, "Mitochondrial defects in neurodegenerative disease", MENT RET D, 7(3), 2001, pp. 158-166

Abstract

Over the past 12 years, a wide variety of neurodegenerative diseases has been linked to mutations in mitochondrial genes located in either the mitochondrial DNA (mtDNA) or the nuclear DNA (nDNA). These disorders encompass anarray of unorthodox inheritance patterns and a plethora of symptoms ranging from lethal neonatal multi-symptom disorders to later onset myopathies, cardiomyopathies, movement disorders, and dementias. The bases for the genetic and phenotypic variability of mitochondrial diseases lie in the multiplicity of the mitochondria genes dispersed across the human genome and the variety of cellular pathways and functions in which the mitochondria play a central role. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:44:20