Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparison of transdermal and oral estrogen-progestin replacement therapy:effects on cardiovascular risk factors
Autore:
Chen, FP; Lee, N; Soong, YK; Huang, KE;
Indirizzi:
Keelung Chang Gung Mem Hosp, Dept Obstet & Gynecol, Chilung, Taiwan Keelung Chang Gung Mem Hosp Chilung Taiwan t & Gynecol, Chilung, Taiwan Keelung Chang Gung Mem Hosp, Dept Clin Pathol, Chilung, Taiwan Keelung Chang Gung Mem Hosp Chilung Taiwan Clin Pathol, Chilung, Taiwan
Titolo Testata:
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 347 - 352
SICI:
1072-3714(200109/10)8:5<347:COTAOE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR; POSTMENOPAUSAL WOMEN; VENOUS THROMBOEMBOLISM; FIBRINOLYTIC SYSTEM; BLOOD-COAGULATION; FACTOR-VII; PLASMA; ESTRADIOL; ASSOCIATION;
Keywords:
postmenopause; oral estrogen-progestin replacement therapy; transdermal estrogen-progestin replacement therapy; lipid profile; hemostatic parameters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, FP Keelung Chang Gung Mem Hosp, Dept Obstet & Gynecol, 222 Mai Chin Rd, Chilung, Taiwan Keelung Chang Gung Mem Hosp 222 Mai Chin Rd Chilung Taiwan iwan
Citazione:
F.P. Chen et al., "Comparison of transdermal and oral estrogen-progestin replacement therapy:effects on cardiovascular risk factors", MENOPAUSE, 8(5), 2001, pp. 347-352

Abstract

Objective: To determine the effects of oral and transdermal hormone replacement therapy on lipid profile and hemostatic factors in postmenopausal women. Design: Twenty subjects were treated with oral E-2 valerate (2 mg) combined with cyproterone acetate (1 mg) (group I) and 21 with transdermal E-2 (1.5 mg) plus oral medroxyprogesterone acetate (5 mg) (group II). The effects on lipid profile and hemostatic parameters were evaluated at baseline and after 3, 6, and 12 months of treatment. Results: Group I showed a stronger increase of high-density lipoprotein (HDL) cholesterol levels (2-8%) and stronger reduction of atherogenic indices(total cholesterol/HDL cholesterol and low-density lipoprotein/HDL cholesterol) than group Il. Group II showed a more pronounced reduction of triglyceride (21-31%) and factor VII (6-10%) levels than group I. Both groups showed reduced concentrations of total cholesterol, low-density lipoprotein cholesterol, tissue plasminogen activator, plasminogen activator inhibitor-1, antithrombin III, and protein S, whereas protein C was increased after 12 months of treatment. Conclusions: The cardioprotective effects of hormone replacement therapy are demonstrated by favorable effects on lipid profile and fibrinolytic activity. Oral hormone replacement therapy showed a more prominent effect on lipoprotein metabolism than did transdermal administration, but transdermal medication had a stronger effect on triglyceride and coagulation factors. However, it needs to be considered that there is an increased risk of venous thrombotic events in the first year of treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:34:25