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Titolo:
Effect of angiotensin II and alpha(2) receptor antagonists on angiotensin II-stimulated nitric oxide release.
Autore:
Jerez, S; De Bruno, MP; Coviello, A;
Indirizzi:
Univ Nacl Tucuman, CONICET, Inst Super Invest Biol, Fac Ciencias Nat, RA-4000 San Miguel De Tucuman, Tucuman, Argentina Univ Nacl Tucuman San MiguelDe Tucuman Tucuman Argentina RA-4000 gentina Univ Nacl Tucuman, CONICET, Inst Super Invest Biol, Inst Miguel Lillo, RA-4000 San Miguel De Tucuman, Tucuman, Argentina Univ Nacl Tucuman San Miguel De Tucuman Tucuman Argentina RA-4000 gentina
Titolo Testata:
MEDICINA-BUENOS AIRES
fascicolo: 4, volume: 61, anno: 2001,
pagine: 431 - 436
SICI:
0025-7680(2001)61:4<431:EOAIAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
SPA
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; SMOOTH-MUSCLE CELLS; INDUCED CONTRACTIONS; ENDOTHELIAL DYSFUNCTION; RABBIT AORTA; BLOCKADE; ARTERY;
Keywords:
angiotensisn II-antagonists; nitric oxide (NO); yohimbine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Jerez, S Espana 3706, RA-4000 San Miguel De Tucuman, Tucuman, Argentina Espana 3706 San Miguel De Tucuman Tucuman Argentina RA-4000 tina
Citazione:
S. Jerez et al., "Effect of angiotensin II and alpha(2) receptor antagonists on angiotensin II-stimulated nitric oxide release.", MEDICINA, 61(4), 2001, pp. 431-436

Abstract

The aim of the present work was to characterize the interaction between the adrenergic system and angiotensin II-stimulated nitric oxide (NO) releasein rabbit aorta. Rings of thoracic aorta were placed in an isolated organ bath. Equilibration was performed during 30 min, and after washing, angiotensin II was added at different concentrations, during 20 min. In another group two stimulations were performed with an interval of 60 min. AngiotensinII antagonists: losartan, PD 123319 and Sar(1)-Leu(8)-angiotensin II, alpha (2)-adrenergic antagonist: yohimbine, all at 10(-5) M and L-NAME or D-NAME 10(-2) M, were added before stimulation with angiotensin II 10(-6) M or 5.10(-6) M. In another group, besides losartan or PD 123319, yohimbine was added. Nitrite determination was performed with Griess reagent. Angiotensin II 10(-8) to 10(-6) M increased NO metabolite production measured as nitrites referred to the control. In higher concentrations there was a diminutionin relation to 10-6 M. Angiotensin II nitrite release fell in the second stimulation with the hormone in all cases, whereas it was blocked by L-NAME,It was increased by angiotensin II antagonist only at maximal concentrations of the hormone, an effect abolished by yohimbine. Likewise, yohimbine diminished nitrite production at concentrations of angiotensin II of 5.10(-6)but not at 10(-6) M. These results allow us to postulate that NO release induced by angiotensin II would be in part mediated by alpha (2) receptors. Angiotensin II antagonists unmask these effects at maximal concentrations of the hormone, whereas at supramaximal concentrations inhibitory mechanismswould prevail, which would be balanced by alpha (2) activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:25:54