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Titolo:
Altered T cell signalling in ageing
Autore:
Pawelec, G; Hirokawa, K; Fulop, T;
Indirizzi:
Univ Tubingen, Sch Med,Tubingen Ageing & Tumour Immunol Grp, Dept InternalMed 2,Zentrum Med Forsch, Sect Transplantat Immunol & Immunohaematol, D-72072 Tubingen, Germany Univ Tubingen Tubingen Germany D-72072 ematol, D-72072 Tubingen, Germany Tokyo Med & Dent Univ, Grad Sch, Dept Pathol & Immunol Aging & Dev Sci, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan Immunol Aging & Dev Sci, Tokyo, Japan Univ Sherbrooke, Inst Geriatrie, Sherbrooke, PQ J1K 2R1, Canada Univ Sherbrooke Sherbrooke PQ Canada J1K 2R1 erbrooke, PQ J1K 2R1, Canada
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 14, volume: 122, anno: 2001,
pagine: 1613 - 1637
SICI:
0047-6374(20010930)122:14<1613:ATCSIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; NF-KAPPA-B; IL-2 RECEPTOR SUBUNITS; DNA-BINDING ACTIVITY; LONG-TERM CULTURE; PERIPHERAL-BLOOD; ELDERLY HUMANS; OLD MICE; IN-VITRO; CYTOKINE PRODUCTION;
Keywords:
T cell; signalling; ageing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Pawelec, G Univ Tubingen, Sch Med,Tubingen Ageing & Tumour Immunol Grp, Dept InternalMed 2,Zentrum Med Forsch, Sect Transplantat Immunol & Immunohaematol, Waldhornlestr 22, D-72072 Tubingen, Germany Univ Tubingen Waldhornlestr 22 Tubingen Germany D-72072 ermany
Citazione:
G. Pawelec et al., "Altered T cell signalling in ageing", MECH AGE D, 122(14), 2001, pp. 1613-1637

Abstract

T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and presentation by antigen presenting cells., suboptimal processing of the antigenic signal by T cells or inability of the T cell to respond appropriately thereafter. This review will focus on altered T cell signalling in ageing, encompassing not only alterations in signal transduction by the antigen-specific T cell receptor, but changes in the balance of positive and negative T cell costimulation and the resultant modified cytokine environment, the response to which is itself altered in ageing. (C) 2001Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:12:57