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Titolo:
Manifestations of gastroesophageal reflux disease in the upper aerodigestive tract.
Autore:
Issing, WJ; Gross, M; Tauber, S;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Klin & Poliklin Hals Nasen & Ohrenkranke, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Ohrenkranke, D-81377 Munich, Germany Univ Munich, Med Poliklin Innenstadt, Munich, Germany Univ Munich MunichGermany ch, Med Poliklin Innenstadt, Munich, Germany
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 8, volume: 80, anno: 2001,
pagine: 464 - 469
SICI:
1615-0007(200108)80:8<464:MOGRDI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
GER
Soggetto:
POSTERIOR LARYNGITIS; ESOPHAGEAL REFLUX; SYMPTOMS; THERAPY; SMOKING; HEAD;
Keywords:
gastroesophageal reflux disease; dysphagia; hoarseness; globus pharyngeus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Issing, WJ Univ Munich, Klinikum Grosshadern, Klin & Poliklin Hals Nasen &Ohrenkranke, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 , Germany
Citazione:
W.J. Issing et al., "Manifestations of gastroesophageal reflux disease in the upper aerodigestive tract.", LARY RH OTO, 80(8), 2001, pp. 464-469

Abstract

Background: Gastroesophageal reflux disease (GERD) is associated with a wide spectrum of otolaryngologic disorders and extraesophageal complications of the upper aerodigestive tract. Previous studies of patients diagnosed with GERD have reported symptoms such as asthma, chronic cough, pneumonia, laryngitis, but also other oral, rhino-pharyngeal and laryngeal disorders, e.g. sore throat, globus sensation, and hoarseness. The objective of this study was to determine the incidence of gastroenterologic diseases in patientscomplaining of upper aerodigestive, pulmonary, laryngeal, pharyngeal, oral, and cervical disorders that are possibly attributable to GERD. Patients: This study included 40 patients, who presented to the department of Otolaryngology with chronic complaints of at least one of the following symptoms or disorders during a minimum period of 3 months: dysphagia (n = 28), sensation of globus pharyngeus (n = 28), hoarseness (n = 20), odynophagia (n = 22), heartburn (n = 16), postnasal drip (n = 15), sore throat (n = 22), cough(n = 14), throat clearing (n = 11), laryngospasm (n = 6), and voice fatigue (n = 6). A complete examination of the head and neck was performed. inflammatory disorders of the nose and the paranasal sinuses could not be confirmed by history, nasal endoscopy and Water's view x-ray or CT-scan of the paranasal sinuses in all patients. Results: The main otorhinolaryngologic findings were laryngeal lesions (n = 38), including posterior laryngitis, erythema and edema of the interarytenoideal region, and chronic hyperplastic laryngitis. All patients were referred for gastroenterologic evaluation, where esophagogastroduodenoscopy was performed with histological examination ofbiopsy specimens. Different gastroenterologic diseases such as GERD, gastritis and hiatal hernia were confirmed in 30 of 40 cases, and appeared solely or in combination with each other. GERD was the most frequent gastroenterologic disease (48 %). followed by hiatal hernia (45 %) and Helicobacter pylori positive antrum gastritis (23%). Patients with GERD were treated with medical antireflux therapy, e.g. 20 mg to 40 mg of the proton pump inhibitor omeprazole daily. There was a remarkably good therapeutic outcome, since laryngeal disorders and findings as the result of gastroenterologic diseases resolved in 29 out of 30 patients. To date, these therapeutic results were maintained for the mean follow-up period of 8 months. Conclusions: it is concluded that in many patients, suffering from the above-mentioned otolaryngologic symptoms, occult gastroesophageal diseases are present. However, laryngoscopic findings are subtle and meticulous examination is mandatory. Medical antireflux treatment is effective for relief of symptoms and mucosalhealing. Thus, extraesophageal otolaryngologic symptoms and laryngeal manifestations are to be considered as extragastrointestinal manifestations mainly of reflux disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:38:49