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Titolo:
Effect of aging and diabetes on the enteroinsular axis
Autore:
Korosi, J; McIntosh, CHS; Pederson, RA; Demuth, HU; Habener, JF; Gingerich, R; Egan, JM; Elahi, D; Meneilly, GS;
Indirizzi:
Univ British Columbia, Dept Med, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada ept Med, Vancouver, BC, Canada Univ British Columbia, Dept Physiol, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada Physiol, Vancouver, BC, Canada Hans Kneoll Inst Nat Prod Res, Halle Saale, Germany Hans Kneoll Inst Nat Prod Res Halle Saale Germany Halle Saale, Germany Harvard Univ, Dept Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ard Univ, Dept Med, Boston, MA 02115 USA Linco Res Inc, St Charles, MO USA Linco Res Inc St Charles MO USALinco Res Inc, St Charles, MO USA NIA, Lab Clin Physiol, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA NIABaltimore MD USA 21224 Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 9, volume: 56, anno: 2001,
pagine: M575 - M579
SICI:
1079-5006(200109)56:9<M575:EOAADO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIPEPTIDYL-PEPTIDASE-IV; DEPENDENT INSULINOTROPIC POLYPEPTIDE; GASTRIC-INHIBITORY POLYPEPTIDE; GLUCAGON-LIKE PEPTIDE-1; HUMAN SERUM; GLUCOSE-TOLERANCE; BETA-CELL; IN-VITRO; HYPOGLYCEMIA; DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Meneilly, GS Vancouver Hosp & Hlth Sci Ctr, Rm S 169,UBC Site 2211,Wesbrook Mall, Vancouver, BC V6T 2B5, Canada Vancouver Hosp & Hlth Sci Ctr Rm S 169,UBC Site 2211,Wesbrook Mall Vancouver BC Canada V6T 2B5
Citazione:
J. Korosi et al., "Effect of aging and diabetes on the enteroinsular axis", J GERONT A, 56(9), 2001, pp. M575-M579

Abstract

Background. The current studies were designed to examine the effect of aging and diabetes on the enteroinsular axis. Methods. Healthy young control subjects (n = 10 young, age 23 +/- 1 years;body mass index [BMI] 24 +/- 1 kg/m(2)), healthy elderly subjects (n = 10;age 80 +/- 2 years; BMI 26 +/- 1 kg/m(2)), and elderly patients with type 2 diabetes (n = 10, age 76 +/- 2 years; BMI 26 +/- 2 kg/m(2)) underwent a 3-hour oral glucose tolerance test (glucose dose 40 gm/m(2)). Results. Insulin responses were not different between young controls and elderly patients with diabetes but were significantly lower in elderly patients with diabetes and young controls than in elderly controls (young control: 178 +/- 27 pM: elderly control: 355 +/- 57 pM elderly diabetes: 177 +/- 30 pM; p < .05 elderly control vs young control and elderly diabetes). Total glucagon-like peptide 1 (GLP-1) responses were not significantly different between young and elderly control, and patients with diabetes (young control: 15 +/- 2 pM; old control: 8 +/- 2 pM; elderly diabetes: 12 +/- 3 pM; p= ns). Active GLP-1 responses were also not different between young and elderly controls and patients with diabetes (young control: 5 +/- 1 pM; old control: 6 +/- 1 pM; elderly diabetes: 7 +/- 1 pM; p = ns). However, the difference between total and active GLP levels was significantly greater in the young controls (young control: 10 +/- 2 pM: old control: 2 +/- 2 pM elderly diabetes: 4 +/- 2 pM; p < .05, young vs elderly). Glucose-dependent insulinotropic polypeptide responses were not different between young and elderly controls and between elderly controls and patients witl diabetes but were significantly higher in elderly patients with diabetes than in young controls (young control: 97 +/- 12 pM; elderly control: 121 +/- 16 pM; elderly diabetes: 173 +/- 27 pM; p < .05, young vs elderly diabetes). Glucagon responses were reduced in elderly controls but were similar in young controls and elderly patients with diabetes (young control: 15 +/- 1 pM; elderly control: 9 +/- 1 pK elderly diabetes: 16 +/- 1 pM: p < .01 elderly control vs young control and elderly diabetes). Dipeptidyl peptidase IV levels were lower in both elderly controls and patients with diabetes when compared with young controls (young control: 0.17 +/- 0.01 elderly control: 0.15 +/- 0.01;elderly diabetes 0.15 +/- 0.01 Delta OD/20 minutes; p < .05, elderly vs young). Conclusions. We conclude that normal aging and diabetes are associated with multiple changes in the enteroinsular axis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:31:05