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Titolo:
Elimination of doxepin isomers from the horse following intravenous application
Autore:
Hagedorn, HW; Meiser, H; Zankl, H; Schulz, R;
Indirizzi:
Univ Munich, Inst Pharmacol Toxicol & Pharm, D-80539 Munich, Germany Univ Munich Munich Germany D-80539 icol & Pharm, D-80539 Munich, Germany
Titolo Testata:
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
fascicolo: 4, volume: 24, anno: 2001,
pagine: 283 - 289
SICI:
0140-7783(200108)24:4<283:EODIFT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DESMETHYLDOXEPIN; PLASMA; ANTIDEPRESSANTS; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hagedorn, HW Univ Munich, Inst Pharmacol Toxicol & Pharm, Koniginstr 16, D-80539 Munich, Germany Univ Munich Koniginstr 16 Munich Germany D-80539 ch, Germany
Citazione:
H.W. Hagedorn et al., "Elimination of doxepin isomers from the horse following intravenous application", J VET PHARM, 24(4), 2001, pp. 283-289

Abstract

The tricyclic antidepressant doxepin, representing a 5:1 mixture of trans-and cis-isomers, owns tranquilizing properties. This compound has been associated with illicit medication of racing horses, and therefore should be considered in doping control. Because analysis of doxepin in equine body fluids has not been documented in the literature, a highly sensitive analytical method was developed to individually monitor the doxepin isomers in bloodand urine of horses by the use of gas chromatography/mass spectrometry. Following a dose of 1 mg doxepin-HCl/kg intravenously (i.v.), both the isomers were quantified for up to 24 h in serum of horses (n = 4). The beta -half-lives of the trans- and cis-isomers were 3.5 and 3.1 h, respectively. The ratio of the trans/cis-isomers was found to be constant (4.7:1) during drugelimination and thus corresponded to the original composition of the antidepressant. Up to 12 h following administration low trams-isomer concentrations in an average range of 2-6 ng/mL were detected in urine of each of the horses, while the cis-isomer was only present in two of four horses for up to 8 and 12 h, respectively. In serum, mean trams-isomer concentrations exceeded urine levels maximally 120-fold after 3 h and at least sixfold after 12 h. As serum exhibits considerably higher concentrations of the doxepin isomers as compared with urine, blood of horses is the recommended body fluid when screening for the antidepressant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 01:49:48