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Titolo:
A novel system for the preparation of orphan receptor ligand peptides
Autore:
Nishimura, O; Koyama, N; Itoh, T; Suenaga, M; Moriya, T; Miwa, M; Tanaka, Y; Kitada, C; Fujino, M;
Indirizzi:
Takeda Chem Ind Ltd, Pharmaceut Discovery Res Div, Discovery Res Labs, Tsukuba, Ibaraki 3004293, Japan Takeda Chem Ind Ltd Tsukuba Ibaraki Japan 3004293 Ibaraki 3004293, Japan Takeda Chem Ind Ltd, Pharmaceut Discovery Res Div, Discovery Res Labs, Yodogawa Ku, Osaka 5328686, Japan Takeda Chem Ind Ltd Osaka Japan 5328686 odogawa Ku, Osaka 5328686, Japan
Titolo Testata:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
fascicolo: 16, , anno: 2001,
pagine: 1960 - 1968
SICI:
1472-7781(20010821):16<1960:ANSFTP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; TERMINAL EXTRA METHIONINE; ESCHERICHIA-COLI; CYANYLATION REACTION; CHEMICAL CLEAVAGE; ALPHA-AMIDATION; RECOMBINANT; EXPRESSION; PROTEINS; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, O Takeda Chem Ind Ltd, Pharmaceut Discovery Res Div, Discovery Res Labs, Wadai 10, Tsukuba, Ibaraki 3004293, Japan Takeda Chem Ind Ltd Wadai 10 Tsukuba Ibaraki Japan 3004293 an
Citazione:
O. Nishimura et al., "A novel system for the preparation of orphan receptor ligand peptides", J CHEM S P1, (16), 2001, pp. 1960-1968

Abstract

A new system is established for the preparation of biologically active recombinant peptides. The system consists of two newly developed chemical methods in combination with recombinant DNA technology. One method is a cleavage reaction by cyanylation from a recombinant fusion protein. The other is ascission reaction of an N-terminal extra-methionine by transamination froma recombinant peptide. This system is successfully established for the synthesis of three orphan receptor ligand peptides; apelin, prolactin-releasing peptide, and galanin-like peptide, isolated in our Research Division. Theresults show that this system is very versatile and might be useful in thepreparation of biologically active peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:10:49