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Titolo:
The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram - A population-based study of four decades
Autore:
Matsuo, K; Akahoshi, M; Nakashima, E; Suyama, A; Seto, S; Hayano, M; Yano, K;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Internal Med 3, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 rnal Med 3, Nagasaki 8528501, Japan Radiat Effects Res Fdn, Nagasaki, Japan Radiat Effects Res Fdn Nagasaki Japan Effects Res Fdn, Nagasaki, Japan Radiat Effects Res Fdn, Hiroshima, Japan Radiat Effects Res Fdn Hiroshima Japan ffects Res Fdn, Hiroshima, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 3, volume: 38, anno: 2001,
pagine: 765 - 770
SICI:
0735-1097(200109)38:3<765:TPIAPV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ST-SEGMENT ELEVATION; IDIOPATHIC VENTRICULAR-FIBRILLATION; BUNDLE-BRANCH BLOCK; 12-LEAD ELECTROCARDIOGRAMS; MECHANISM; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuo, K Nagasaki Univ, Sch Med, Dept Internal Med 3, 1-7-1 Sakamoto, Nagasaki 8528501, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 8501, Japan
Citazione:
K. Matsuo et al., "The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram - A population-based study of four decades", J AM COL C, 38(3), 2001, pp. 765-770

Abstract

OBJECTIVES We sought to demonstrate the prevalence, incidence and prognostic value of the Brugada-type electrocardiogram (ECG) in a general population. BACKGROUND The Brugada syndrome is characterized by evidence of right bundle branch block and ST segment elevation in the right precordial leads, as well as sudden death caused by ventricular fibrillation. However, the natural history of the Brugada-type ECG remains unclear. METHODS We investigated 4,788 subjects (1,956 men and 2,832 women) who were < 50 years old in 1958 and had undergone biennial health examinations, including electrocardiography, through 1999. The Brugada-type ECG was definedas a terminal r ' wave in lead V-1 and ST segment elevation greater than or equal to0.1 mV in leads V-1 and V-2. Unexpected death was defined as sudden death or unexplained accidental death. RESULTS There were a total of 32 Brugada-type ECG cases; the prevalence and incidence were 146.2 in 100,000 persons and 14.2 persons per 100,000 person-years, respectively. The incidence was nine times higher among men than women, and the average age at presentation was 45 +/- 10.5 years. The Brugada-type ECG appeared intermittently in most cases and was found in 26% of subjects who died unexpectedly. Cox survival analysis revealed that mortality from unexpected death was significantly higher in subjects with a Brugada-type ECG than in control subjects (p < 0.01). Unexpected deaths were more frequent among subjects with the Brugada-type ECG who had a history of syncope (p < 0.05). CONCLUSIONS The Brugada-type ECG is not a very rare condition in the adultJapanese population. Subjects with a Brugada-type ECG have an increased risk of unexpected death. (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:21:26