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Titolo:
TIMI frame count immediately after primary coronary angioplasty as a predictor of functional recovery in patients with TIMI 3 reperfused acute myocardial infarction
Autore:
Hamada, S; Nishiue, T; Nakamura, S; Sugiura, T; Kamihata, H; Miyoshi, H; Imuro, Y; Iwasaka, T;
Indirizzi:
Kansai Med Univ, Ctr Cardiovasc, Moriguchi, Osaka 5708507, Japan Kansai Med Univ Moriguchi Osaka Japan 5708507 guchi, Osaka 5708507, Japan Kochi Med Sch, Dept Clin Lab Med, Kochi, Japan Kochi Med Sch Kochi Japan ochi Med Sch, Dept Clin Lab Med, Kochi, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 3, volume: 38, anno: 2001,
pagine: 666 - 671
SICI:
0735-1097(200109)38:3<666:TFCIAP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO-REFLOW PHENOMENON; BLOOD-FLOW; ELECTROCARDIOGRAPHIC EVIDENCE; SUCCESSFUL THROMBOLYSIS; ARTERY OCCLUSION; WALL-MOTION; FOLLOW-UP; THERAPY; TRIAL; VIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hamada, S Kansai Med Univ, Ctr Cardiovasc, 10-15 Fumizono Cho, Moriguchi, Osaka 5708507, Japan Kansai Med Univ 10-15 Fumizono Cho Moriguchi Osaka Japan 5708507
Citazione:
S. Hamada et al., "TIMI frame count immediately after primary coronary angioplasty as a predictor of functional recovery in patients with TIMI 3 reperfused acute myocardial infarction", J AM COL C, 38(3), 2001, pp. 666-671

Abstract

OBJECTIVES The purpose of this study was to evaluate whether higher coronary blood flow, estimated by the corrected Thrombolysis In Myocardial Infarction (TIMI) frame count (CTFC), is related to better functional and clinical outcome after successful percutaneous transluminal coronary angioplasty (PTCA) in patients with acute myocardial infarction (AMI). BACKGROUND Experimental studies have found that functional recovery of theinfarcted myocardium was associated with increased blood flow (reactive hyperemia) to the infarcted bed shortly after reperfusion. METHODS We measured CTFC immediately after successful (TIMI 3) primary PTCA in 104 consecutive patients with their first AMI. Wall motion score index(WMSI) and the presence of pericardial effusion were assessed by two-dimensional echocardiography before and one month after PTCA. RESULTS The patients were divided into two groups according to mean CTFC for corresponding coronary artery of the control group: TIMI 3 slow group (45 patients, 40 > CTFC greater than or equal to 23) and TIMI 3 fast group (59 patients, CTFC < 23). There were no significant differences in the baseline characteristics and WMSI before reperfusion between the two groups. Improvement of WMSI in the TIMI 3 fast group was significantly greater than that of the TIMI 3 slow group (1.33 +/- 0.52 vs. 0.60 +/- 0.34, p < 0.001). Pericardial effusion and intractable heart failure were observed more frequently in the TIMI 3 slow group than in the TIMI 3 fast group (27 vs. 10%; p <0.05, 36 vs. 17%; p < 0.05). Corrected TIMI frame count, assessed as a continuous variable, had a significant correlation with the change in WMSI (r = 0.60, p < 0.001) after adjusting for age, gender, history of hypertension, history of diabetes, elapsed time to PTCA, collateral grade, presence of antegrade flow before PTCA and number of diseased vessels. CONCLUSIONS Lower CTFC of the infarct-related artery immediately after PTCA was associated with greater functional recovery; :and hence, CTFC can predict clinical and functional outcome in patients with successful PTCA. (C) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:56:35