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Titolo:
MNDPDP ENHANCEMENT IN RABBIT LIVER AFTER INTRAVENOUS BOLUS INJECTION AND SLOW INFUSION
Autore:
THORSTENSEN O; ISBERG B; JORULF H; WESTMAN L; SVAHN U; VENIZELOS N;
Indirizzi:
SJUKRAHUS REYKJAVIKUR,DIAGNOST RADIOL IS-108 REYKJAVIK ICELAND HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT DIAGNOST RADIOL S-14186 HUDDINGE SWEDEN HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT CLIN CHEM S-14186 HUDDINGE SWEDEN
Titolo Testata:
Acta radiologica
fascicolo: 4, volume: 38, anno: 1997,
parte:, 2
pagine: 717 - 723
SICI:
0284-1851(1997)38:4<717:MEIRLA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANGANESE DIPYRIDOXAL DIPHOSPHATE; MRI CONTRAST AGENT; MN-DPDP;
Keywords:
LIVER, CONTRAST AGENTS; MR, MANGAFODIPIR TRISODIUM; ENHANCEMENT, MANGANESE; EXPERIMENTAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
O. Thorstensen et al., "MNDPDP ENHANCEMENT IN RABBIT LIVER AFTER INTRAVENOUS BOLUS INJECTION AND SLOW INFUSION", Acta radiologica, 38(4), 1997, pp. 717-723

Abstract

Purpose: To investigate the MR-enhancing effect of mangafodipir trisodium (MnDPDP, Teslascan) in the rabbit liver in relation to dose, modeof administration and imaging window. Material and Methods: MnDPDP was administered to 18 rabbits at a dose of 10 mu mol/kg or 20 mu mol/kg, as a bolus injection or infusion. MR imaging of the liver was performed at different time intervals. Results: Peak liver enhancement was typically observed 10-30 min after administration and the enhancement declined with a half-time of about 5 h. This pattern was observed in all sequences (SE 400/15, FLASH, and SE 132/10), with both doses and with both rates of administration. The peak enhancement was greater, though not significantly so after 20 mu mol/kg than after 10 mu mol/kg. A higher relative peak signal was observed with SE 132/10 than with FLASH or SE 400/15. Conclusion: A good liver imaging result was obtained after a dose of 10 mu mol/kg, either bolus or infusion, 10-30 min post-contrast with heavily T1-weighted sequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:59:09