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Titolo:
Non-serotonergic pharmacological profiles and associated cognitive effectsof serotonin reuptake inhibitors
Autore:
Schmitt, JAJ; Kruizinga, MJ; Riedel, WJ;
Indirizzi:
Univ Maastricht, Expt Psychopharmacol Unit, Dept Psychiat & Neuropsychol DRT10, Brain & Behav Inst, NL-6200 MD Maastricht, Netherlands Univ Maastricht Maastricht Netherlands NL-6200 MD aastricht, Netherlands
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 173 - 179
SICI:
0269-8811(200109)15:3<173:NPPAAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL WORKING-MEMORY; TRYPTOPHAN DEPLETION; PSYCHOMOTOR PERFORMANCE; PROLACTIN RESPONSE; PLASMA PROLACTIN; ANTIDEPRESSANTS; PAROXETINE; DOPAMINE; SCOPOLAMINE; DEPRESSION;
Keywords:
cognition drug-effects; memory; paroxetine; serotonin-uptake-inhibitor pharmacology; sertraline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitt, JAJ Univ Maastricht, Expt Psychopharmacol Unit, Dept Psychiat & Neuropsychol DRT10, Brain & Behav Inst, POB 616, NL-6200 MD Maastricht, Netherlands Univ Maastricht POB 616 Maastricht Netherlands NL-6200 MD ds
Citazione:
J.A.J. Schmitt et al., "Non-serotonergic pharmacological profiles and associated cognitive effectsof serotonin reuptake inhibitors", J PSYCHOPH, 15(3), 2001, pp. 173-179

Abstract

The current study was carried out to investigate the cognitive effects of two serotonin reuptake inhibitors (SSRIs), sertraline and paroxetine, with special reference to differences in their affinity for other neurotransmitter systems, i.e. anticholinergic activity of paroxetine and putative dopamine reuptake activity of sertraline. The study was conducted according to a double-blind, three-way cross-over design. During three treatment periods of 2 weeks, 24 healthy middle-aged (aged 30-50 years) subjects of both sexesreceived sertraline (50 mg on days 1-7, 100 mg on days 8-14), paroxetine (20 mg on days 1-7, 40 mg on days 8-14) and placebo. Paroxetine specificallyimpaired delayed recall in a word learning test at a dose of 20 and 40 mg. Sertraline did not affect word learning but improved performance on a verbal fluency task at a dose of 50 and 100 mg. Neither drug affected performance on a short-term memory scanning task. These subtle but significant changes in cognitive performance can be explained by subtle differences in pharmacological profiles of these SSRIs. The additional anticholinergic effects of paroxetine could account for its induction of long-term memory impairment. Similarly, the additional dopaminergic effects of sertraline could account for its induction of slightly improved verbal fluency. The impairing andfacilitating cognitive effects of paroxetine and sertraline, respectively,may be more pronounced in the elderly depressed patient.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:45:42