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Titolo:
The effects of dimenhydrinate, cinnarizine and transdermal scopolamine on performance
Autore:
Gordon, CR; Gonen, A; Nachum, Z; Doweck, I; Spitzer, O; Shupak, A;
Indirizzi:
Israel Naval Med Inst, Mot Sickness & Human Performance Lab, IDF Med Corps, IL-31080 Haifa, Israel Israel Naval Med Inst Haifa Israel IL-31080 orps, IL-31080 Haifa, Israel Meir Hosp, Dept Neurol, Kefar Sava, Israel Meir Hosp Kefar Sava IsraelMeir Hosp, Dept Neurol, Kefar Sava, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 167 - 172
SICI:
0269-8811(200109)15:3<167:TEODCA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTION SICKNESS; PSYCHOLOGICAL PERFORMANCE; PSYCHOMOTOR PERFORMANCE; INDUCED PARKINSONISM; TIME COURSE; PREVENTION; SEASICKNESS; SEA; DIPHENHYDRAMINE; EFFICACY;
Keywords:
cinnarizine; dimenhydrinate; drowsiness; performance; scopolamine; seasickness; sedation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, CR Israel Naval Med Inst, Mot Sickness & Human Performance Lab, IDF Med Corps, POB 8040, IL-31080 Haifa, Israel Israel Naval Med Inst POB 8040 Haifa Israel IL-31080 a, Israel
Citazione:
C.R. Gordon et al., "The effects of dimenhydrinate, cinnarizine and transdermal scopolamine on performance", J PSYCHOPH, 15(3), 2001, pp. 167-172

Abstract

We assessed the influence of dimenhydrinate, cinnarizine and transdermal scopolamine on the ability to perform simulated naval crew tasks. The effectof single doses of dimenhydrinate, 100 mg, cinnarizine, 50 mg, and one transdermal scopolamine patch on psychomotor performance was evaluated using adouble-blind, placebo-controlled, randomized, crossover design in three separate studies. A total of 60 young naval crew (20 for dimenhydrinate, 15 for cinnarizine and 25 for transdermal scopolamine) underwent a battery of computerized and paper and pencil performance tests, and filled out a questionnaire on side-effects and well-being self-assessment. Dimenhydrinate significantly impaired decision reaction time and auditory digit span. Most of the subjects who took dimenhydrinate also reported a subjective decrease inwell-being and general performance abilities. Cinnarizine and transdermal scopolamine did not affect performance abilities. Cinnarizine was free of significant side-effects. Dry mouth was the only significant side-effect of transdermal scopolamine. These findings could be explained by the well-known sedative properties of dimenhydrinate and not by a specific effect on anyparticular cognitive or motor function. Our results suggest that dimenhydrinate, 100 mg, adversely affects psychomotor function, whereas single dosesof cinnarizine, 50 mg, and transdermal scopolamine appear to be free of side-effects on performance and seem to be a preferable anti-seasickness drugfor use by a naval crew.

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Documento generato il 14/11/18 alle ore 03:11:15