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Titolo:
Schwann cells and oligodendrocytes read distinct signals in establishing myelin sheath thickness
Autore:
Elder, GA; Friedrich, VL; Lazzarini, RA;
Indirizzi:
CUNY Mt Sinai Sch Med, Dept Biochem & Mol Biol, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 Biol, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA CUNY Mt SinaiSch Med New York NY USA 10029 chiat, New York, NY 10029 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 6, volume: 65, anno: 2001,
pagine: 493 - 499
SICI:
0360-4012(20010915)65:6<493:SCAORD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXON DIAMETER; NERVE-FIBERS; NEUROFILAMENT DEFICIENCY; CONDUCTION-VELOCITY; TRANSGENIC MICE; EXPRESSION; MODULATION; CALIBER; TRANSPORT; SUBUNIT;
Keywords:
neurofilament proteins; mice; knockout; myelin sheath thickness; oligodendrocyte; Schwann cell; signals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Lazzarini, RA CUNY Mt Sinai Sch Med, Dept Biochem & Mol Biol, Box 1126, New York, NY 10029 USA CUNY Mt Sinai Sch Med Box 1126 New York NY USA 10029 029 USA
Citazione:
G.A. Elder et al., "Schwann cells and oligodendrocytes read distinct signals in establishing myelin sheath thickness", J NEUROSC R, 65(6), 2001, pp. 493-499

Abstract

Schwann cells and oligodendrocytes produce myelin sheaths of widely varying sizes. How these cells determine the size of myelin sheath for a particular axon is incompletely understood. Axonal diameter has long been suspectedto be a signal in this process. We have analyzed myelin sheath thickness in L5 lumbar root and spinal cord white matter of a series of mouse mutants with diminished axonal calibers resulting from a deficiency of neurofilaments (NFs). In the PNS, average axonal diameters were reduced by 20-37% in the NF mutants. Remarkably, the average myelin sheath thickness remained unchanged from control values, and regression analysis showed sheaths abnormally thick for a given size of axon. These data show that a genetically induced reduction in axonal caliber does not cause a reduction in myelin sheath thickness in PNS and indicate that Schwann cells read some intrinsic signal on axons that can be uncoupled from axonal diameter. Interestingly, myelin sheaths in the spinal cord of these animals were not abnormally thick, arguing that axonal diameter may contribute directly to the regulation of myelination in the CNS and that oligodendrocytes and Schwann cells use differentcues to set myelin sheath thickness. J. Neurosci. Res. 65:493-499, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:46:21