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Titolo:
Simultaneous determination of losartan potassium and hydrochlorothiazide from tablets and human serum by RP-HPLC
Autore:
Ozkan, SA;
Indirizzi:
Hacettepe Univ, Fac Pharm, Dept Analyt Chem, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 alyt Chem, TR-06100 Ankara, Turkey
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 15, volume: 24, anno: 2001,
pagine: 2337 - 2346
SICI:
1082-6076(2001)24:15<2337:SDOLPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HUMAN PLASMA; BENAZEPRIL HYDROCHLORIDE; CAPILLARY-ELECTROPHORESIS; COZAAR(R) TABLETS; MAJOR METABOLITE; DRUG SUBSTANCE; URINE; SPECTROPHOTOMETRY; FORMULATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ozkan, SA Hacettepe Univ, Fac Pharm, Dept Analyt Chem, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 TR-06100 Ankara, Turkey
Citazione:
S.A. Ozkan, "Simultaneous determination of losartan potassium and hydrochlorothiazide from tablets and human serum by RP-HPLC", J LIQ CHR R, 24(15), 2001, pp. 2337-2346

Abstract

A new, simple, precise, rapid, and accurate RP-HPLC method has been developed for the simultaneous determination of losartan potassium and hydrochlorothiazide from tablets and human serum. Chromatography was carried out on aC-18 reversed-phase column using a mixture of 0.01 M KH2PO4: acetonitrile (65:35; v/v) adjusted to pH 3.1 with H3PO4 at a flow rate 1.0 mL/min. Detection was realised at 232 mn using a UV detector. Linearity was obtained in the concentration range of 25-10000 ng/mL and 50-10000 ng/mL for losartan potassium and hydrochlorothiazide, respectively. The limit of detection and the limit of quantification of the procedure were found to be 1.02 ng/mL and 3.39 ng/mL for losartan potassium; 4.49 ng/mL and 14.96 ng/mL for hydrochlorothiazide, respectively. This method was succesfully applied without any interferences to the simultaneous analysis of losartan potassium and hydrochlorothiazide in human serum and pharmaceutical dosage forms in the presence of each other.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:57:33