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Titolo:
Simultaneous liquid chromatographic determination of Indinavir Saquinavir,and Ritonavir in human plasma with combined ultraviolet absorbance and electrochemical detection
Autore:
Marchei, E; Pacifici, R; Tossini, G; Di Fava, R; Valvo, L; Zuccaro, P;
Indirizzi:
Ist Super Sanita, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 st Super Sanita, I-00161 Rome, Italy RCCS, Ist Nazl Malattie Infett, Rome, Italy RCCS Rome ItalyRCCS, Ist Nazl Malattie Infett, Rome, Italy
Titolo Testata:
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
fascicolo: 15, volume: 24, anno: 2001,
pagine: 2325 - 2336
SICI:
1082-6076(2001)24:15<2325:SLCDOI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-PROTEASE INHIBITORS; IMMUNODEFICIENCY-VIRUS INFECTION; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; SOCIETY-USA PANEL; ANTIRETROVIRAL THERAPY; UPDATED RECOMMENDATIONS; NELFINAVIR; AMPRENAVIR; QUANTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Zuccaro, P Ist Super Sanita, Viale Regina Elena 299, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299 Rome Italy I-00161 aly
Citazione:
E. Marchei et al., "Simultaneous liquid chromatographic determination of Indinavir Saquinavir,and Ritonavir in human plasma with combined ultraviolet absorbance and electrochemical detection", J LIQ CHR R, 24(15), 2001, pp. 2325-2336

Abstract

A method is described for the simultaneous determination of protease inhibitors Indinavir, Saquinavir, and Ritonavir in human plasma using liquid chromatography with ultraviolet and electrochemical detection, Sample pre-treatment consisted of solid-phase extraction prior to ion-pair reversed phase high performance liquid chromatography with ultraviolet detection at 240 nm(Saquinavir and Ritonavir) and electrochemical detection at + 750 mV (Indinavir and Saquinavir). The method was validated with respect to specificity, linearity, limits of detection and quantification, precision, and accuracy. The proposed LC assay was utilized to analyze plasma samples from patients treated with HIV-protease inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:45:24