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Titolo:
Effects of isolated limb perfusion with tumor necrosis factor-alpha on circulating levels of proinflammatory cytokines
Autore:
Ferroni, P; Di Filippo, F; Martini, F; Spila, A; DAlessandro, R; Cavaliere, F; Anza, M; Garinei, R; Aloe, S; Carone, MD; Gazzaniga, PP; Guadagni, F;
Indirizzi:
Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy Univ Roma La Sapienza Rome Italy I-00161 d & Pathol, I-00161 Rome, Italy Regina Elena Inst Canc Res, Dept Surg, Rome, Italy Regina Elena Inst Canc Res Rome Italy Canc Res, Dept Surg, Rome, Italy Regina Elena Inst Canc Res, Clin Pathol Lab, Rome, Italy Regina Elena InstCanc Res Rome Italy Res, Clin Pathol Lab, Rome, Italy
Titolo Testata:
JOURNAL OF IMMUNOTHERAPY
fascicolo: 4, volume: 24, anno: 2001,
pagine: 354 - 362
SICI:
1524-9557(200107/08)24:4<354:EOILPW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LUNG INJURY; INTERFERON-GAMMA; SYSTEMIC TOXICITY; CANCER-PATIENTS; HUMAN-MELANOMA; RTNF-ALPHA; TNF-ALPHA; COAGULATION; MELPHALAN; ACTIVATION;
Keywords:
isolated limb perfusion; TNF alpha; cytokines; selectins; systemic inflammatory response syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ferroni, P Univ Roma La Sapienza, Dept Expt Med & Pathol, Viale Regina Elena 324, I-00161 Rome, Italy Univ Roma La Sapienza Viale Regina Elena 324 Rome Italy I-00161
Citazione:
P. Ferroni et al., "Effects of isolated limb perfusion with tumor necrosis factor-alpha on circulating levels of proinflammatory cytokines", J IMMUNOTH, 24(4), 2001, pp. 354-362

Abstract

Hyperthermic isolated limb perfusion (ILP) with tumor necrosis factor-alpha (TNF alpha) and cytotoxic drugs is currently used for treatment of melanoma and sarcoma of the limbs. Tumor necrosis factor-alpha is involved in thesystemic inflammatory response syndrome as a result of activation of inflammatory cells and production of bioactive substances. The goal of this study was to determine the circulating levels of proinflammatory cytokines and soluble adhesion molecules in 19 patients with limb melanoma or sarcoma undergoing ILP with (n = 9) or without TNF alpha (n = 10). The results obtained demonstrated that ILP with TNF alpha was responsible for a leakage of TNFalpha in the systemic circulation, followed by a rise in interleukin (IL)-6 and IL-8 levels within 1 h. Elevated soluble (s)P-selectin levels were found 1-3 h after ILP. Plasma sE-selectin peaked 6-9 h after ILP, and solublevascular cell adhesion molecule (sVCAM) levels reached a maximum after 24 h. Significant correlations were observed among these variables, confirmingthe interdependence of all changes observed. On the other hand, ILP with cytotoxic drugs alone induced only a modest release of TNF alpha, which was not followed by an immediate rise in IL-6 and IL-8. Four of the 9 patients undergoing ILP with TNF had severe systemic toxicity. No association was found between systemic TNF levels and the clinical outcome, whereas elevated TNF perfusion levels as well as systemic IL-6 and IL-8 levels were constantly elevated in patients with severe toxicity. These results are suggestive of an important role of TNF alpha levels in the perfusion system (more thanleakage of perfusate) in causing postoperative toxicity, although other ILP-related factors should not be excluded.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:48:02