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Titolo:
Decreased vascular glucose transporter expression and glucose uptake in DOCA-salt hypertension
Autore:
Atkins, KB; Johns, D; Watts, S; Webb, RC; Brosius, FC;
Indirizzi:
Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nternal Med, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Physiol, Ann Arbor, MI 48109 USA Ann Arbor Vet Affairs Hosp, Ann Arbor, MI USA Ann Arbor Vet Affairs Hosp Ann Arbor MI USA airs Hosp, Ann Arbor, MI USA
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 9, volume: 19, anno: 2001,
pagine: 1581 - 1587
SICI:
0263-6352(200109)19:9<1581:DVGTEA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; GROWTH-FACTOR; DIFFERENTIAL REGULATION; INSULIN SENSITIVITY; RAT; CONTRACTION; HORMONE; ARTERY;
Keywords:
glucose transporter; glucose uptake; hypertension; vascular reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Brosius, FC Univ Michigan, Sch Med, Dept Internal Med, 1560 MSRBII,1150 W Med Ctr, AnnArbor, MI 48109 USA Univ Michigan 1560 MSRBII,1150 W Med Ctr Ann Arbor MI USA 48109
Citazione:
K.B. Atkins et al., "Decreased vascular glucose transporter expression and glucose uptake in DOCA-salt hypertension", J HYPERTENS, 19(9), 2001, pp. 1581-1587

Abstract

Objective Because glucose uptake and metabolism can affect vascular smoothmuscle cell function, we proposed that animals with hypertension might develop alterations in glucose transporter expression in vascular smooth muscle cells that were responsible for some of the vascular abnormalities characteristic of hypertension. Design and method Male Sprague-Dawley rats (250-300 g) were left uni-nephrectomized and either implanted or not with deoxycorticosterone acetate (DOCA, 200 mg/ kg) impregnated silastic. All animals were fed normal rat chow. The DOCA-implanted rats were given water supplemented to 1% NaCl and 0.2% KCl for 7,14 or 28 days. Results The insulin-response glucose transporter (GLUT4) polypeptide levels were depressed several-fold in aortae and carotid arteries from DOCA-salthypertensive rats compared with sham rats. Uptake of the glucose analog, 2-deoxyglucose (2-DOG), was also reduced 53% in hypertensive compared with sham aortae. There were no changes in GLUT4 expression in other tissues in the DOCA-salt animals, nor were there significant changes in aortae from spontaneously hypertensive rat/stroke prone animals. As previously demonstrated, carotid arteries from DOCA-salt animals exhibited a significant increased contractile sensitivity to ergonovine. Inhibition of glucose metabolism with 2-DOG in sham arteries caused a marked enhancement of contractile responsiveness to ergonovine, whereas 2-DOG had no effect on the already enhanced contractility of DOCA-salt arteries, suggesting that reduction in glucoseuptake and metabolism substantially increases the contractile response of DOCA-salt arteries. Conclusions Alterations in glucose uptake and metabolism in vascular smooth muscle cells may participate in the contractile abnormalities characteristic of certain forms of hypertension. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:49:31