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Titolo:
Thirteen single-nucleotide polymorphisms in the human osteopontin gene identified by sequencing of the entire gene in Japanese individuals
Autore:
Iwasaki, H; Shinohara, Y; Ezura, Y; Ishida, R; Kodaira, M; Kajita, M; Nakajima, T; Shiba, T; Emi, M;
Indirizzi:
Nippon Med Coll, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 211, Japan Nippon Med Coll Kawasaki Kanagawa Japan 211 Kawasaki, Kanagawa 211, Japan Kitasato Univ, Dept Mol Biol, Sagamihara, Kanagawa 228, Japan Kitasato Univ Sagamihara Kanagawa Japan 228 gamihara, Kanagawa 228, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 9, volume: 46, anno: 2001,
pagine: 544 - 546
SICI:
1434-5161(2001)46:9<544:TSPITH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA REPEAT SEQUENCE; CLONING; LOCUS; BONE;
Keywords:
single-nucleotide polymorphism; direct sequencing; Japanese population; ethnic difference; bone metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Emi, M Nippon Med Coll, Inst Gerontol, Dept Mol Biol, Nakahara Ku, 1-396 Kosugi Cho, Kawasaki, Kanagawa 211, Japan Nippon Med Coll 1-396 Kosugi Cho Kawasaki Kanagawa Japan 211 Japan
Citazione:
H. Iwasaki et al., "Thirteen single-nucleotide polymorphisms in the human osteopontin gene identified by sequencing of the entire gene in Japanese individuals", J HUM GENET, 46(9), 2001, pp. 544-546

Abstract

Osteopontin (OPN) is one of the major noncollagenous bone matrix proteins produced by osteoblasts and osteoclasts. We systematically surveyed the entire structure of the OPN gene for single-nucleotide polymorphisms (SNPs) bydirectly sequencing 48 alleles derived from 24 unrelated Japanese individuals. We identified 13 SNPs in the OPN gene. Ten polymorphisms were identified in introns 1, 3, and 5; 2 in the coding region of exons 6 and 7; and I in the 3' untranslated region of exon 7. Allele frequencies for some of the polymorphisms were significantly different from those reported in the United States National Center for Biotechnology Information (NCBI) dbSNP database. These polymorphisms will be useful in genetic studies to evaluate the role of OPN proteins in bone metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/18 alle ore 08:15:04