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Titolo:
An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis
Autore:
Kawamoto, R; Kohara, K; Tabara, Y; Miki, T; Doi, T; Tokunaga, H; Konishi, I;
Indirizzi:
Nomura Municipal Hosp, Dept Internal Med, Nomura, Ehime 7971212, Japan Nomura Municipal Hosp Nomura Ehime Japan 7971212 ra, Ehime 7971212, Japan Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan Ehime Univ Matsuyama Ehime Japan 790 atr Med, Matsuyama, Ehime 790, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 9, volume: 46, anno: 2001,
pagine: 506 - 510
SICI:
1434-5161(2001)46:9<506:AAO5R(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; THERMOLABILE METHYLENETETRAHYDROFOLATE REDUCTASE; PLASMA TOTAL HOMOCYSTEINE; MYOCARDIAL-INFARCTION; RISK FACTOR; ISCHEMIC STROKE; C677T MUTATION; FOLATE; THROMBOSIS; INCREASES;
Keywords:
carotid atherosclerosis; risk factor; MTHFR gene polymorphism; age; interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kawamoto, R Nomura Municipal Hosp, Dept Internal Med, 9-53 Nomura, Nomura,Ehime 7971212, Japan Nomura Municipal Hosp 9-53 Nomura Nomura Ehime Japan 7971212 n
Citazione:
R. Kawamoto et al., "An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis", J HUM GENET, 46(9), 2001, pp. 506-510

Abstract

Plasma homocysteine (Hcy) concentration has been shown to be influenced bya mutation in the gene coding methylenetetrahydrofolate reductase (MTHFR). Although plasma Hcy is related to atherosclerotic disorders, conflicting results have been reported about the association between MTHFR gene polymorphism and sclerotic lesions of the common carotid arteries. The effect of age-gene interaction on carotid arterial remodeling was investigated in elderly subjects with several risk factors for atherosclerosis. We evaluated sclerotic lesions of the common carotid arteries by ultrasonography in 326 patients (mean age +/- standard deviation, 73 +/- 12 years) and studied relations among the known risk factors for atherosclerosis, including MTHFR gene polymorphism and its interactions with age and sex. Of the 326 subjects studied, 136 had MTHFR genotype CC, 136 genotype CT. and 54 genotype TT. The three groups did not differ with respect to background factors such as age, history of cigarette smoking, blood pressure, lipids or uric acid. or in the incidence of atherosclerotic diseases. Spearman's rank correlation revealed a significant relationship between gender. age, Brinkman index. systolicblood pressure, triglycerides, HDL-cholesterol (HDL-C). uric acid, and MTHFR gene polymorphism. Multiple regression analysis using intimamedia complex thickness (IMT) as a criterion variable and risk factors. including MTHFRgene polymorphism as explanatory variables showed that MTHFR gene polymorphism (P = 0.039) was a significant independent explanatory variable for IMT. along with gender (male) (P < 0.001), age (P < 0.001), systolic blood pressure (SBP) (P = 0.047), total cholesterol (T-C) (P < 0.001), and HDL-C (P < 0.001). Furthermore. a general linear model analysis revealed that interaction between age and MTHFR gene polymorphism was significantly associated with IMT, independently of age, SBP, T-C, and HDL-C in male subjects. However. age-gene interaction was not observed in female subjects. The findings of the present study confirm an association between MTHFR gene polymorphismand common carotid atherosclerosis in the Japanese population and further support the role of risk factor-gene interaction in common carotid atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:31:26