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Titolo:
Serum lipoprotein(a) concentration as a cardiovascular risk factor in Kuwaiti Type 2 diabetic patients
Autore:
Abdella, NA; Mojiminiyi, OA; Akanji, AO; Al Mohammadi, H; Moussa, MAA;
Indirizzi:
Kuwait Univ, Fac Med, Dept Med, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 v, Fac Med, Dept Med, Safat 13110, Kuwait Kuwait Univ, Fac Med, Dept Pathol, Safat, Kuwait Kuwait Univ Safat Kuwait wait Univ, Fac Med, Dept Pathol, Safat, Kuwait Kuwait Univ, Fac Med, Dept Community Med, Safat, Kuwait Kuwait Univ Safat Kuwait iv, Fac Med, Dept Community Med, Safat, Kuwait
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 5, volume: 15, anno: 2001,
pagine: 270 - 276
SICI:
1056-8727(200109/10)15:5<270:SLCAAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HUMAN-ENDOTHELIAL-CELLS; OXIDATIVE STRESS; LP(A) CONCENTRATIONS; METABOLIC CONTROL; ARAB POPULATION; MELLITUS; COMPLICATIONS; INSULIN; MEN;
Keywords:
lipoprotein(a); diabetes mellitus; coronary heart disease; diabetic complications; Kuwaiti Arabs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Abdella, NA Kuwait Univ, Fac Med, Dept Med, POB 24923, Safat 13110, KuwaitKuwait Univ POB 24923 Safat Kuwait 13110 Safat 13110, Kuwait
Citazione:
N.A. Abdella et al., "Serum lipoprotein(a) concentration as a cardiovascular risk factor in Kuwaiti Type 2 diabetic patients", J DIABET C, 15(5), 2001, pp. 270-276

Abstract

Serum lipoprotein(a) [Lp(a)], a risk factor for coronary heart disease (CHID) in some nondiabetic populations, is largely under genetic control and varies among ethnic and racial groups. We evaluated serum Lp(a) concentration and its relationship with traditional CHD fisk factors (age, sex, smoking, hypertension, dyslipidemia) as well as stage of diabetic nephropathy in 345 type 2 diabetic patients. Lp(a) concentration was skewed with median (2.5th, 97.5th percentiles) of 25.0 (8.1, 75.7) mg/dl. Twenty-three of 55 (41.8%) patients with CHD had increased (>30 mg/dl) Lp(a) compared with 102 of 290 (35.1%) patients without CHID ( P=.35). Twelve of 27 (44.4%) female patients with CHD had increased Lp(a) compared to 11 of 28 (39.3%) males ( P=.70). Lp(a) was significantly (P<.05) higher in females than males, but the logistic regression analysis showed significant association of Lp(a), LDL-C, and duration of diabetes mellitus (DM) vith CHD in male patients only. Although female patients with CHD and macroalbuminuria had significantly (P<.05) higher Lp(a) than normoalbuminuric female patients without CHD, no suchassociation was found in males and no significant association was found between Lp(a) and the degree of albuminuria. Partial correlation analysis controlling for age, sex, and BMI showed significant correlation of Lp(a) withtotal cholesterol only (P=.03) and no correlation was found with other lipid parameters. Multiple regression analysis did not show significant associations of Lp(a) with standard CHD risk factors, HbA(1c), and plasma creatinine. This study is in agreement with studies in other populations, which showed that Lp(a) may not be an independent risk factor for CHD in patients with DM. However, as Lp(a) could promote atherogenesis via several mechanisms, follow-up studies in our patients will confirm if increased Lp(a) concentration can partly account for the poorer prognosis when diabetic patients develop CHID. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 23:35:13