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Titolo:
Comparison of laser-Doppler flowmetry with biochemical indicators of endothelial dysfunction related to early microangiopathy in Type 1 diabetic patients
Autore:
Skrha, J; Prazny, M; Haas, T; Kvasnicka, J; Kalvodova, B;
Indirizzi:
Charles Univ, Fac Med 1, Dept Internal Med 3, Prague 12808, Czech RepublicCharles Univ Prague Czech Republic 12808 3, Prague 12808, Czech Republic Charles Univ, Fac Med 1, Dept Hematol, Prague, Czech Republic Charles Univ Prague Czech Republic Dept Hematol, Prague, Czech Republic Charles Univ, Fac Med 1, Dept Ophthalmol, Prague, Czech Republic Charles Univ Prague Czech Republic t Ophthalmol, Prague, Czech Republic
Titolo Testata:
JOURNAL OF DIABETES AND ITS COMPLICATIONS
fascicolo: 5, volume: 15, anno: 2001,
pagine: 234 - 240
SICI:
1056-8727(200109/10)15:5<234:COLFWB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYL-BETA-GLUCOSAMINIDASE; CIRCULATING ADHESION MOLECULES; MICROVASCULAR BLOOD-FLOW; OXIDATIVE STRESS; SKIN MICROCIRCULATION; GLYCEMIC CONTROL; E-SELECTIN; MELLITUS; IDDM; NIDDM;
Keywords:
laser-Doppler; biochemical markers; endothelial dysfunction; Type 1 diabetes mellitus; microangiopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Skrha, J Charles Univ, Fac Med 1, Dept Internal Med 3, U Nemocnice 1, Prague 12808,Czech Republic Charles Univ U Nemocnice 1 Prague Czech Republic 12808 Republic
Citazione:
J. Skrha et al., "Comparison of laser-Doppler flowmetry with biochemical indicators of endothelial dysfunction related to early microangiopathy in Type 1 diabetic patients", J DIABET C, 15(5), 2001, pp. 234-240

Abstract

The aim of this study was to compare biochemical markers of endothelial activation with microcirculation measured by laser-Doppler flowmetry in Type 1 diabetic patients with or without microangiopathy. A total of 44 Type 1 diabetic patients were subdivided into those with (n=24) and without (n=20) microangiopathy according to opthalmological findings and the presence or absence of microalbuminuria. The control group consisted of 25 healthy people of comparable age, sex, and body mass index. Postocclusive reactive hyperemia (PORH) and thermal hyperemia (TH, at 44 degreesC) were measured at theforearm. Serum N-acetyl-beta -glucosaminidase (NAG) activity, serum E-selectin, and ICAM-1 concentrations were used as biochemical markers of endothelial dysfunction. A significantly lower velocity of perfusion increase during postocclusive hyperemia (PORHmax.t(1)(-1)) and during thermal hyperemia (THmax.t(2)(-1)) (P<.01) were accompanied by higher serum NAG activity (20.9<plus/minus>4.6 vs. 16.3 +/-2.5 U 1(-1), P<.01) in diabetic patients with microangiopathy as compared to healthy persons. An inverse relationship wasfound between PORHmax.t(1)(-1) and NAG (r= -.33) results in diabetic patients. In addition, higher mean values of serum NAG activity, E-selectin, andICAM-1 concentrations were associated with significantly lower values of microcirculation parameters (PORHmax.t(2)(-1) and THmax.t(2)(-1)) in six patients without microangiopathy who had at least one of the above biochemicalmarkers higher than mean + 2 S.D. range. We suggest that serum NAG activity, E-selectin, and ICAM-1 concentrations may be used together with laser-Doppler flowmetry in Type 1 diabetic patients as early indicators of vascularchanges in very early stage of diabetic Microangiopathy. (C) 2001 ElsevierScience Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:24:37