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Titolo:
Effects of experimental strabismus on the architecture of macaque monkey striate cortex
Autore:
Fenstemaker, SB; Kiorpes, L; Movshon, JA;
Indirizzi:
NYU, Howard Hughes Med Inst, New York, NY 10003 USA NYU New York NY USA 10003 Howard Hughes Med Inst, New York, NY 10003 USA NYU, Ctr Neural Sci, New York, NY 10003 USA NYU New York NY USA 10003NYU, Ctr Neural Sci, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 438, anno: 2001,
pagine: 300 - 317
SICI:
0021-9967(20010924)438:3<300:EOESOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCULAR DOMINANCE COLUMNS; PRIMARY VISUAL-CORTEX; CALCIUM-BINDING PROTEINS; NITRIC-OXIDE SYNTHASE; CALBINDIN IMMUNOREACTIVITY; NEUROFILAMENT PROTEIN; NADPH DIAPHORASE; NEURONS; AMBLYOPIA; PATHWAYS;
Keywords:
visual cortex; cytochrome oxidase; ocular dominance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Fenstemaker, SB NYU, Howard Hughes Med Inst, 4 Washington Pl,Room 809, NewYork, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 003 USA
Citazione:
S.B. Fenstemaker et al., "Effects of experimental strabismus on the architecture of macaque monkey striate cortex", J COMP NEUR, 438(3), 2001, pp. 300-317

Abstract

Strabismus, a misalignment of the eyes, results in a loss of binocular visual function in humans. The effects are similar in monkeys, where a loss ofbinocular convergence onto single cortical neurons is always found. Changes in the anatomical organization of primary visual cortex (V1) may be associated with these physiological deficits, yet few have been reported. We examined the distributions of several anatomical markers in V1 of two experimentally strabismic Macaca nemestrina monkeys. Staining patterns in tangential sections were related to the ocular dominance (OD) column structure as deduced from cytochrome oxidase (CO) staining. CO staining appears roughly normal in the superficial layers, but in layer 4C, one eye's columns were pale. Thin, dark stripes falling near OD column borders are evident in Nissl-stained sections in all layers and in immunoreactivity for calbindin, especially in layers 3 and 4B. The monoclonal antibody SMI32, which labels a neurofilament protein found in pyramidal cells, is reduced in one eye's columnsand absent at OD column borders. The pale SMI32 columns are those that aredark with CO in layer 4. Gallyas staining for myelin reveals thin stripes through layers 2-5; the dark stripes fall at OD column centers. All these changes appear to be related to the loss of binocularity in cortical neurons, which has its most profound effects near OD column borders. J. Comp. Neurol. 438:300-317, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:20:26