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Titolo:
Age-related decline of presumptive inhibitory synapses in the sensorimotorcortex as revealed by the physical disector
Autore:
Poe, BH; Linville, C; Brunso-Bechtold, J;
Indirizzi:
Wake Forest Univ, Sch Med, Neurosci Program, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Sch Med, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 439, anno: 2001,
pagine: 65 - 72
SICI:
0021-9967(20011008)439:1<65:ADOPIS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL SUPERIOR OLIVE; SYNAPTIC DENSITY; CEREBRAL-CORTEX; BASAL FOREBRAIN; COGNITIVE DECLINE; VISUAL-CORTEX; RATS; NEURONS; HIPPOCAMPUS; INTERNEURONS;
Keywords:
electron microscopy; quantitative anatomy; stereology; synaptic vesicles; ultrastructure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Poe, BH Univ Connecticut, Ctr Hlth, Dept Neurosci, MC 3401,263 Farmington Ave, Farmington, CT 06030 USA Univ Connecticut MC 3401,263 Farmington Ave Farmington CT USA 06030
Citazione:
B.H. Poe et al., "Age-related decline of presumptive inhibitory synapses in the sensorimotorcortex as revealed by the physical disector", J COMP NEUR, 439(1), 2001, pp. 65-72

Abstract

The synapse, as the site of functional neural interaction, has been suggested as a possible substrate for age-related impairment of cognitive ability. Using the physical disector probe with tissue prepared for ultrastructural analysis, we find an age-related decline in the numerical density of presumptive inhibitory synapses in layer 2 of the sensorimotor cortex of the Brown Norway X Fisher 344 rat. This age-related decline in presumptive inhibitory synapses is maintained when the density of synapses is combined with the numerical density of neurons quantified from the same anatomical space to arrive at a ratio of synapses per neuron. The numerical density of these synapses declines between middle-aged (18 months) and old (29 months) animals by 36% whereas numerical density of neurons does not change between these ages, resulting in a decline in the ratio of presumptive inhibitory synapses per neuron in this cortical area. This study demonstrates a deficit in the intrinsic inhibitory circuitry of the aging neocortex, which suggests an anatomical substrate for age-related cognitive impairment. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:52:47