Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D-2 receptor parameter measurements inventral striatum
Autore:
Mawlawi, O; Martinez, D; Slifstein, M; Broft, A; Chatterjee, R; Hwang, DR; Huang, YY; Simpson, N; Ngo, K; Van Heertum, R; Laruelle, M;
Indirizzi:
New York State Psychiat Inst & Hosp, Dept Analyt Pharmacol, Div Funct Brain Mapping, New York, NY 10032 USA New York State Psychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 9, volume: 21, anno: 2001,
pagine: 1034 - 1057
SICI:
0271-678X(200109)21:9<1034:IHMDTW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 RACLOPRIDE BINDING; PARTIAL-VOLUME CORRECTION; HUMAN-BRAIN; CONTINUOUS-INFUSION; I-125 EPIDEPRIDE; AUTORADIOGRAPHIC LOCALIZATION; PERFORMANCE EVALUATION; AUTOMATED ALGORITHM; PET DATA; AMPHETAMINE;
Keywords:
dopamine; D-2 receptor; nucleus accumbens; partial volume effects; positron emission tomography; [C-11]Raclopride; ventral striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Mawlawi, O New York State Psychiat Inst & Hosp, Dept Analyt Pharmacol, DivFunct Brain Mapping, 1051 Riverside Dr,Unit 31, New York, NY 10032 USA NewYork State Psychiat Inst & Hosp 1051 Riverside Dr,Unit 31 New York NY USA 10032
Citazione:
O. Mawlawi et al., "Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D-2 receptor parameter measurements inventral striatum", J CEREBR B, 21(9), 2001, pp. 1034-1057

Abstract

Dopamine transmission in the ventral striatum (VST), a structure which includes the nucleus accumbens. ventral caudate, and ventral putamen, plays a critical role in the pathophysiology of psychotic states and in the reinforcing effects of virtually all drugs of abuse. The aim of this study was to assess the accuracy and precision of measurements of D-2 receptor availability in the VST obtained with positron emission tomography on the high-resolution ECAT EXACT HR+ scanner (Siemens Medical Systems, Knoxville, TN, U.S.A.). A method was developed for identification of the boundaries of the VST on coregistered high-resolution magnetic resonance imaging scans. Specific-to-nonspecific partition coefficient (V-3") and binding potential (BP) of [C-11]raclopride were measured twice in 10 subjects, using the bolus plus constant infusion method. [C-11]Raclopride V-3" in the VST (1.86 +/- 0.29) was significantly lower than in the dorsal caudate (DCA, 2.33 +/- 0.28) and dorsal putamen (DPU, 2.99 +/- 0.26), an observation consistent with postmortem studies. The reproducibility of V-3" and BP were appropriate and similarin VST (V-3" test-retest variability of 8.2% +/- 6.2%. intraclass correlation coefficient = 0.83). DCA (7.7% +/- 5.1%, 0.77). DPU (6.0% +/- 4.1%, 0.71), and striatum as a whole (6.3% +/- 4.1%, 0.78). Partial volume effects analysis revealed that activities in the VST were significantly contaminatedby counts spilling over from the adjacent DCA and DPU: 70% +/- 5% of the specific binding measured in the VST originated from D-2 receptors located in the VST, whereas 12% +/- 3% and 18% +/- 3% were contributed by D-2 receptors in the DCA and DPU, respectively. Thus, accuracy of D-2 receptor measurement is improved by correction for partial voluming effects. The demonstration of an appropriate accuracy and precision of D2 receptor measurement with [C-11]raclopride in the VST is the first critical step toward the use ofthis ligand in the study of synaptic dopamine transmission at D2 receptorsin the VST using endogenous competition techniques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:08:46