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Titolo:
Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction
Autore:
Schmitt, H; Cabo, C; Coromilas, JC; Wit, AL;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Pharmacol, Ctr Mol Therapeut, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 9, volume: 12, anno: 2001,
pagine: 1025 - 1033
SICI:
1045-3873(200109)12:9<1025:EOAANC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-RECTIFIER CURRENT; D-SOTALOL; EXCITABLE GAP; AGENT; NE-10064; EFFICACY; REPOLARIZATION; ARRHYTHMIAS; DEPENDENCE; BLOCK;
Keywords:
potassium channels; ventricular tachycardia; ventricular fibrillation; antiarrhythmic drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Wit, AL Columbia Univ Coll Phys & Surg, Dept Pharmacol, Ctr Mol Therapeut,630 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St New York NY USA 10032
Citazione:
H. Schmitt et al., "Effects of azimilide, a new class III antiarrhythmic drug, on reentrant circuits causing ventricular tachycardia and fibrillation in a canine model of myocardial infarction", J CARD ELEC, 12(9), 2001, pp. 1025-1033

Abstract

Introduction: Azimilide blocks the slow (I-Ks) and fast (I-Kr) components of the delayed rectifier potassium channel. It also has blocking effects onsodium (IN.) and calcium currents (I-CaL). Its effects on reentrant circuits in infarct border zones causing ventricular tachyarrhythmias are unknown. Methods and Results: Activation in reentrant circuits causing sustained ventricular tachycardia (SVT) and the initial polymorphic tachycardia that leads to ventricular fibrillation (VF) was mapped in the epicardial border zone (EBZ) of 4-day-old canine infarcts. Azimilide prolonged the effective refractory period (ERP) in both normal myocardium and EBZ, but reverse use-dependence in EBZ was prominent. Azimilide abolished SVT initiation by programmed electrical stimulation by prolonging the ERP at the site of stimulation either in normal or EBZ, preventing the occurrence of early premature impulses and the formation of lines of block in the EBZ necessary for formation of reentrant circuits. Azimilide prevented VF initiation by programmed electrical stimulation by causing conduction block of reentrant impulses in the EBZ during the initial beats of rapid polymorphic ventricular tachycardia, despite the reverse use-dependent effects on ERP. Conclusion: Azimilide has antiarrhythmic effects to prevent reentry causing SVT and VF in a canine infarct model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:56:10