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Titolo:
Effect of gender on atrial electrophysiologic changes induced by rapid atrial pacing and elevation of atrial pressure
Autore:
Tse, HF; Oral, H; Pelosi, F; Knight, BP; Strickberger, SA; Morady, F;
Indirizzi:
Univ Michigan, Med Ctr, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Div Cardiol, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 9, volume: 12, anno: 2001,
pagine: 986 - 989
SICI:
1045-3873(200109)12:9<986:EOGOAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC MYOCYTES; GUINEA-PIG; FIBRILLATION; 17-BETA-ESTRADIOL; REFRACTORINESS; VERAPAMIL;
Keywords:
gender; atrial fibrillation; atrial refractory period;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Morady, F Univ Michigan, Med Ctr, Dept Internal Med, Div Cardiol, 1500 E Med Ctr Dr,B1F245, Ann Arbor, MI 48109 USA Univ Michigan 1500 E Med Ctr Dr,B1F245 Ann Arbor MI USA 48109 SA
Citazione:
H.F. Tse et al., "Effect of gender on atrial electrophysiologic changes induced by rapid atrial pacing and elevation of atrial pressure", J CARD ELEC, 12(9), 2001, pp. 986-989

Abstract

Introduction: The incidence of atrial fibrillation is greater in men than in women, but the reasons for this gender difference are unclear. The purpose of this study was to evaluate the effects of gender on the atrial electrophysiologic effects of rapid atrial pacing and an increase in atrial pressure. Methods and Results: Right atrial pressure and effective refractory period(ERP) were measured during sinus rhythm and during atrial and simultaneousAV pacing at a cycle length of 300 msec in 10 premenopausal women, 11 postmenopausal women, and 24 men. The postmenopausal women were significantly older than the premenopausal women (61 +/-8 years vs 34 +/- 10 years; P<0.01). During sinus rhythm, mean atrial ERP in premenopausal women was shorter (211<plus/minus>19 msec) than in postmenopausal women and age-matched men (242 +/- 18 msec and 246 +/- 34 msec, respectively; P<0.05). Atrial ERPs in all patients shortened significantly during atrial and simultaneous AV pacing. However, the degree of shortening during atrial pacing (43<plus/minus>8msec vs 70 +/- 20 msec and 74 +/- 21 msec; P<0.05) and during simultaneousAV pacing (48<plus/minus>16 msec vs 91 +/- 27 msec and 84 +/- 26 msec; P<0.05) was significantly less in premenopausal women than in postmenopausal women or age-matched men. Conclusion: The results of this study demonstrate a significant gender difference in atrial electrophysiologic changes in response to rapid atrial pacing and an increase in atrial pressure. The effect of menopause on the observed changes suggests that the gender differences may be mediated by the effects of estrogen on atrial electrophysiologic properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:39:15