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Titolo:
Hepatocellular carcinoma - Correlation between vascular endothelial growthfactor level and degree of enhancement by multiphase contrast-enhanced computed tomography
Autore:
Kwak, BK; Shim, HJ; Park, ES; Kim, SA; Choi, D; Lim, HK; Park, CK; Chung, JW; Park, JH;
Indirizzi:
Chung Ang Univ, Coll Med, Yongsan Hosp, Dept Radiol,Cardiovasc Ctr, Seoul 156756, South Korea Chung Ang Univ Seoul South Korea 156756 c Ctr, Seoul 156756, South Korea Chung Ang Univ, Coll Med, Yongsan Hosp, Dept Pathol, Seoul 156756, South Korea Chung Ang Univ Seoul South Korea 156756 athol, Seoul 156756, South Korea Sung Ae Gen Hosp, Dept Radiol, Seoul, South Korea Sung Ae Gen Hosp SeoulSouth Korea osp, Dept Radiol, Seoul, South Korea Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul, South Korea Sungkyunkwan Univ Seoul South Korea tr, Dept Radiol, Seoul, South Korea Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Diagnost Pathol, Seoul, South Korea Sungkyunkwan Univ Seoul South Korea Diagnost Pathol, Seoul, South Korea Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ Hosp, Inst Radiat Med, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea
Titolo Testata:
INVESTIGATIVE RADIOLOGY
fascicolo: 8, volume: 36, anno: 2001,
pagine: 487 - 492
SICI:
0020-9996(200108)36:8<487:HC-CBV>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR GENE-EXPRESSION; PERMEABILITY FACTOR; HELICAL CT; CLINICAL-SIGNIFICANCE; INDUCED ANGIOGENESIS; CELLS SECRETE; BREAST-TUMORS; LIVER; PURIFICATION; INHIBITION;
Keywords:
vascular endothelial growth factor; computed tomography; contrast enhancement; liver computed tomography; liver neoplasms; blood supply; liver neoplasms; computed tomography; computed tomography; helical; hepatocellular carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Park, JH Seoul Natl Univ, Coll Med, Dept Radiol, 28 Yongon Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 th Korea
Citazione:
B.K. Kwak et al., "Hepatocellular carcinoma - Correlation between vascular endothelial growthfactor level and degree of enhancement by multiphase contrast-enhanced computed tomography", INV RADIOL, 36(8), 2001, pp. 487-492

Abstract

RATIONALE AND OBJECTIVES. To determine whether vascular endothelial growthfactor (VEGF) is a histopathological factor influencing contrast enhancement of hepatocellular carcinoma (HCC) on computed tomography (CT). METHODS. Twenty-two nodular HCCs underwent multiphase helical CT and surgery. Tumor size, histological grading of differentiation, and type of hepatitis were evaluated. Tumor attenuation was graded as hyperattenuated, isoattenuated, and hypoattenuated. Immunohistochemical staining with anti-VEGF antibody was performed and scored as weak, intermediate, or strong. Spearman's rank correlation test was used. RESULTS. Tumors ranged from 1.0 to 12.0 cm (mean 5.1 cm). The degree of enhancement during the hepatic arterial phase was significantly correlated with VEGF expression. Size was negatively correlated with VEGF expression andthe degree of enhancement, but histological grade and type of hepatitis were not correlated with VEGF expression, tumor size, or degree of enhancement. CONCLUSIONS. In HCC, VEGF expression is correlated with the degree of contrast enhancement during arterial-phase CT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:32:26