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Titolo:
THE GENE FOR THE HUMAN INTERLEUKIN-11 RECEPTOR-ALPHA CHAIN LOCUS IS HIGHLY HOMOLOGOUS TO THE MURINE GENE AND CONTAINS ALTERNATIVELY SPLICEDFIRST EXONS
Autore:
NANDURKAR HH; ROBB L; NICHOLL JK; HILTON DJ; SUTHERLAND GR; BEGLEY CG;
Indirizzi:
WALTER & ELIZA HALL INST MED RES PARKVILLE VIC 3050 AUSTRALIA COOPERAT CTR CELLULAR GROWTH FACTORS PARKVILLE VIC 3050 AUSTRALIA ROYAL MELBOURNE HOSP,ROTARY BONE MARROW RES LABS PARKVILLE VIC 3050 AUSTRALIA WOMENS & CHILDRENS HOSP,DEPT CYTOGENET & MOL GENET,CTR MED GENET ADELAIDE SA 5006 AUSTRALIA
Titolo Testata:
International journal of biochemistry & cell biology
fascicolo: 5, volume: 29, anno: 1997,
pagine: 753 - 766
SICI:
1357-2725(1997)29:5<753:TGFTHI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; LEUKEMIA-INHIBITORY FACTOR; HUMAN ERYTHROPOIETIN RECEPTOR; CARCINOMA CELL-LINE; SIGNAL-TRANSDUCTION; HEMATOPOIETIC CYTOKINE; MOLECULAR-CLONING; EXPRESSION; TRANSCRIPTION; ORGANIZATION;
Keywords:
CYTOKINE RECEPTOR; INTERLEUKIN-11 RECEPTOR; HIL-11R-ALPHA; GENE STRUCTURE; ALTERNATIVE SPLICING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H.H. Nandurkar et al., "THE GENE FOR THE HUMAN INTERLEUKIN-11 RECEPTOR-ALPHA CHAIN LOCUS IS HIGHLY HOMOLOGOUS TO THE MURINE GENE AND CONTAINS ALTERNATIVELY SPLICEDFIRST EXONS", International journal of biochemistry & cell biology, 29(5), 1997, pp. 753-766

Abstract

The gene for the murine interleukin-ll receptor a chain (mIL-11R alpha) contains two loci (1 and 2), of which locus 2 is restricted to onlysome mouse strains. Two alternatively spliced exons (la and Ib) encode the 5' untranslated region (5'UTR) of the murine locus 1. We have characterized the gene for the human interleukin-ll receptor a chain locus (hIL-11R alpha), examined its expression by Northern analysis and determined its chromosomal location by fluorescence in situ hybridization. The presence of exon(s) encoding the 5'UTR and mapping of transcription initiation sites was determined by reverse-transcriptase polymerase chain reaction and 5' rapid amplification of cDNA ends (5'RACE) techniques, The human locus spanned 10 kilobasepairs (kb) and consisted of 14 exons. Two alternatively spliced first exons (la and Ib) encoding the 5'UTR were identified and shared 76 and 73% nucleotide identity with murine exons la and Ib. Multiple transcription start sites were demonstrated for human exon la. The promoter regions of both human exons la and Ib did not display a canonical TATA box. A predominant 1.8 kbtranscript for the hIL-11R alpha was present in heart, brain, skeletal muscle, lymph nodes, thymus, appendix, pancreas and foetal liver. The hIL-11R alpha gene was localized to chromosome 9p13. In summary, thehIL-11R alpha gene was highly related to locus 1 of the murine gene and there was no evidence of a second hIL-11R alpha locus. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:28:57