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Titolo:
Origin of endothelial cells from mesothelial-derived mesenchymal cells in the liver of avian embryos
Autore:
Munoz-Chapuli, R; Carmona, R; Gonzalez-Iriarte, M; Perez-Pomares, JM; Macias, D; Atencia, G; Aranda, MJ;
Indirizzi:
Univ Malaga, Fac Ciencias, Dept Anim Biol, Malaga, Spain Univ Malaga Malaga Spain a, Fac Ciencias, Dept Anim Biol, Malaga, Spain Med Univ S Carolina, Dept Cell Biol & Anat, Charleston, SC USA Med Univ S Carolina Charleston SC USA ll Biol & Anat, Charleston, SC USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
, volume: 45, anno: 2001, supplemento:, 1
pagine: S143 - S144
SICI:
0214-6282(2001)45:<S143:OOECFM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBEPICARDIAL MESENCHYME; EPICARDIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Munoz-Chapuli, R Univ Malaga, Fac Ciencias, Dept Anim Biol, Malaga, Spain Univ Malaga Malaga Spain Dept Anim Biol, Malaga, Spain
Citazione:
R. Munoz-Chapuli et al., "Origin of endothelial cells from mesothelial-derived mesenchymal cells in the liver of avian embryos", INT J DEV B, 45, 2001, pp. S143-S144

Abstract

We have tested the hypothesis of an origin of mesenchyme from the coelomicmesothelium of the developing avian liver and the differentiation of sinusoidal endothelial cells from mesothelial-derived mesenchymal cells. Our results have shown that 1) Mesothelial cells of the developing liver and the submesothelial mesenchymal cells are simultaneously cytokeratin (CK) and vimentin (VIM) immunoreactive between HH18 and HH28.2) A number of early sinusoidal cells are also CK immunoreactive. In the quail, CK colocalizes with the vascular marker QH1 in these cells. 3) In late embryos (>HH30), only themesothelium remains CK+. 4) Mesothelial and submesothelial mesenchymal cells express the transcription factors Slug and WT1, both related to the epithelial-mesenchymal transition. 5) When the surface mesothelium was stained in vivo with CCFSE, a carboxyfluorescein derivative, isolated sinusoidal cells were labelled after 24-48 h, These observations suggest that mesenchymal cells originate from the coelomic mesothelium of the developing liver anddifferentate into endothelial cells of the hepatic sinusoids.

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Documento generato il 06/04/20 alle ore 05:44:25